S
Sushama Sivakumar
Researcher at University of Texas Southwestern Medical Center
Publications - 19
Citations - 1686
Sushama Sivakumar is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Kinetochore & Mitosis. The author has an hindex of 11, co-authored 16 publications receiving 1360 citations. Previous affiliations of Sushama Sivakumar include University of Oklahoma & Oklahoma Medical Research Foundation.
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Journal ArticleDOI
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.
Sungyul Lee,Florian Kopp,Tsung Cheng Chang,Anupama Sataluri,Beibei Chen,Sushama Sivakumar,Hongtao Yu,Yang Xie,Joshua T. Mendell +8 more
TL;DR: The initial functional analysis of a poorly characterized human lncRNA that is induced after DNA damage is described, introducing a mechanism that regulates the activity of a deeply conserved and highly dosage-sensitive family of RNA binding proteins and reveal unanticipated roles for a lnc RNA and PUMILIO proteins in the maintenance of genomic stability.
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Spatiotemporal regulation of the anaphase-promoting complex in mitosis
TL;DR: The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute to tumorigenesis.
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Ska3 Is Required for Spindle Checkpoint Silencing and the Maintenance of Chromosome Cohesion in Mitosis
John R. Daum,Jonathan D. Wren,Jeremy J. Daniel,Sushama Sivakumar,Jennifer N. McAvoy,Tamara A. Potapova,Gary J. Gorbsky,Gary J. Gorbsky +7 more
TL;DR: It is suggested that this network plays a major role in silencing the spindle checkpoint when chromosomes are aligned at metaphase to allow timely anaphase onset and mitotic exit.
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Cohesion Fatigue Induces Chromatid Separation in Cells Delayed at Metaphase
John R. Daum,Tamara A. Potapova,Sushama Sivakumar,Jeremy J. Daniel,Jennifer N. Flynn,Susannah Rankin,Susannah Rankin,Gary J. Gorbsky,Gary J. Gorbsky +8 more
TL;DR: During experimentally induced metaphase delay, spindle pulling forces can cause asynchronous chromatid separation, a phenomenon the authors term "cohesion fatigue" that constitutes a previously overlooked source for chromosome instability in mitosis and meiosis.
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Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited
TL;DR: Inhibition of positive feedback prevents rapid Cdk1 activation and induces a mitotic “collapse” phenotype characterized by the dephosphorylation of mitotic substrates without cyclin B proteolysis.