Scott Lonning

TL;DR: It is demonstrated that TGF-β signaling regulates glucose tolerance and energy homeostasis and suggested that modulation of T GF-β activity might be an effective treatment strategy for obesity and diabetes.

TL;DR: It is demonstrated that tumor cells directly convert CD4+CD25− T cells to Treg cells through production of high levels of TGF-β, suggesting a possible mechanism through which tumor cells evade the immune system.

TL;DR: Using transplantable models of breast and colon cancer, the unexpected finding that CD8+ cells in tumor-bearing animals can directly promote tumorigenesis, by a mechanism that is dependent on TGF-beta is made.

TL;DR: The use of TGF-β inhibitors with radiation to improve therapeutic response in patients with GBM is motivated by data that suggest GIC promotes effective DNA damage response and self-renewal, which creates microenvironment-mediated resistance.

TL;DR: It is shown that efficacy of the anti-TGF-beta antibody 1D11 in suppressing metastasis was dependent on a synergistic combination of effects on both the tumor parenchyma and microenvironment and the absence of a major effect of TGF- beta antagonism on any one cell compartment may be critical for a good therapeutic window and the avoidance of autoimmune complications.