Christina H. Stuelten

TL;DR: It is demonstrated that TGF-β signaling regulates glucose tolerance and energy homeostasis and suggested that modulation of T GF-β activity might be an effective treatment strategy for obesity and diabetes.

TL;DR: In this Review, insights relevant to human cancer that are derived from the study of cell motility in non-mammalian model organisms are evaluated, including the detailed signalling network that governs chemotaxis towards chemokines.

TL;DR: Focusing on models involving epithelial-to-mesenchymal transition (EMT), including injury to the lens and retina of the eye and to the kidney, it is found that loss of Smad3 blocks EMT and attenuates development of fibrotic sequelae.

TL;DR: Biglycan and decorin appear to be essential for maintaining an appropriate number of mature osteoblasts by modulating the proliferation and survival of bone marrow stromal cells, and underscore the importance of the micro-environment in controlling the fate of adult stem cells.

TL;DR: The results indicate that MMP-9 levels in tumor fibroblasts are regulated by a complex tumor-stroma cross-talk, involving multiple ligands and cellular signaling pathways.