S
Sussan Nourshargh
Researcher at Queen Mary University of London
Publications - 148
Citations - 16130
Sussan Nourshargh is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Inflammation & Cell adhesion molecule. The author has an hindex of 59, co-authored 146 publications receiving 14197 citations. Previous affiliations of Sussan Nourshargh include National Institutes of Health & University of Cambridge.
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Journal ArticleDOI
PECAM-1, α6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration
TL;DR: The findings suggest that, whereas regulation of the expression of α6 integrins and NE occur via different adhesive mechanisms, these molecules might act in a cooperative manner in mediating neutrophil migration through venular walls, in particular the perivascular basement membrane.
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Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome.
Olaya Santiago-Fernández,Fernando G. Osorio,Víctor Quesada,Francisco Rodríguez,Sammy Basso,Daniel Maeso,Loïc Rolas,Anna Barkaway,Sussan Nourshargh,Alicia R. Folgueras,José M.P. Freije,Carlos López-Otín +11 more
TL;DR: The efficacy of a CRISPR/Cas9-based approach that reverts several alterations in Hutchinson–Gilford progeria syndrome cells and mice by introducing frameshift mutations in the LMNA gene is explored.
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ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia
Abigail Woodfin,Martina Beyrau,Mathieu-Benoit Voisin,Bin Ma,James R. Whiteford,Peter L. Hordijk,Nancy Hogg,Sussan Nourshargh +7 more
TL;DR: Light is shed on regulation of expression and function of ICAM-1 on neutrophils and it is identified as an additional regulator of neutrophil effector responses in host defense.
Journal Article
A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8.
Sussan Nourshargh,J. A. Perkins,H. J. Showell,Koji Matsushima,Timothy J. Williams,Paul D. Collins +5 more
TL;DR: In vivo studies of the biologic activity of the two predominant forms of IL-8 show that both forms are equipotent in inducing inflammatory responses in vivo, and demonstrates that, in vitro, human rIL-8(72) is more potent than human ril-8 (77) in stimulating neutrophils.
Journal Article
The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo.
Lúcia Helena Faccioli,Sussan Nourshargh,Redwan Moqbel,F.M. Williams,Roma Sehmi,A. B. Kay,Timothy J. Williams +6 more
TL;DR: A system to measure the accumulation of 111In-eosinophils in guinea-pig skin in vivo and the techniques described will facilitate analysis of the mechanisms involved in eos inophil accumulation in defined inflammatory reactions are developed.