S
Sussan Nourshargh
Researcher at Queen Mary University of London
Publications - 148
Citations - 16130
Sussan Nourshargh is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Inflammation & Cell adhesion molecule. The author has an hindex of 59, co-authored 146 publications receiving 14197 citations. Previous affiliations of Sussan Nourshargh include National Institutes of Health & University of Cambridge.
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Journal ArticleDOI
Neutrophil transmigration: emergence of an adhesive cascade within venular walls.
TL;DR: The present review aims to provide a brief summary of novel additions to the classical adhesion cascade within the vascular lumen and to discuss the emergence of a secondAdhesion cascade for neutrophils within venular walls, the latter illustrating the intricacies and complexities of neutrophil transmigration.
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A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.
Vincenzo Brancaleone,Thomas Gobbetti,Nicolas Cenac,Pauline Le Faouder,Pauline Le Faouder,Bartomeu Colom,Roderick J. Flower,Nathalie Vergnolle,Sussan Nourshargh,Mauro Perretti +9 more
TL;DR: It is proposed that during ischemia, neutrophil Fpr2/3 controls platelet/neutrophil aggregates with the rapid generation of circulating LXA4, which in turn modulates downstream vascular inflammatory responses evident during the reperfusion phase.
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Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo.
Richard Thompson,Matthew W. Wakelin,Karen Y. Larbi,Ann Dewar,George Asimakopoulos,Michael A. Horton,Marian T. Nakada,Sussan Nourshargh +7 more
TL;DR: Findings indicate roles for both PECAM-1 and β3 integrins in leukocyte extravasation, but do not support the concept that these molecules act as counter-receptors in mediating leukocytes transmigration.
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Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo.
Federica M. Marelli-Berg,Martha J. James,John P. Dangerfield,Julian Dyson,Maggie Millrain,Diane Scott,Elizabeth Simpson,Sussan Nourshargh,Robert I. Lechler +8 more
TL;DR: The results are consistent with the hypothesis that, under inflammatory conditions, antigen presentation by the endothelium contributes to the development and specificity of T-cell-mediated inflammation by favoring the selective migration of antigen-specific T cells.
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Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.
Michaela Finsterbusch,Mathieu-Benoit Voisin,Martina Beyrau,Timothy J. Williams,Sussan Nourshargh +4 more
TL;DR: Adherent neutrophils responding to chemoattractants release TNF in proximity of endothelial cell junctions to mediate microvascular leakage.