S
Sussan Nourshargh
Researcher at Queen Mary University of London
Publications - 148
Citations - 16130
Sussan Nourshargh is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Inflammation & Cell adhesion molecule. The author has an hindex of 59, co-authored 146 publications receiving 14197 citations. Previous affiliations of Sussan Nourshargh include National Institutes of Health & University of Cambridge.
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Journal ArticleDOI
Recent developments and complexities in neutrophil transmigration.
TL;DR: A better understanding of the tissue-specific and stimulus-specific mechanisms that mediate neutrophil transmigration may identify novel pathways that could be exploited for the development of more specific anti-inflammatory interventions.
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Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation.
TL;DR: Key aspects of the current understanding of the dynamics and mechanisms that regulate the expression of endothelial cells junctional molecules during inflammation are summarized and the associated functional implications of such events in acute and chronic scenarios are discussed.
Journal ArticleDOI
Junctional Adhesion Molecule-C Regulates the Early Influx of Leukocytes into Tissues during Inflammation
Michel Aurrand-Lions,Chrystelle Lamagna,John P. Dangerfield,Shijun Wang,Pedro Luis Herrera,Sussan Nourshargh,Beat A. Imhof +6 more
TL;DR: It is shown that the accumulation of leukocytes in alveoli during acute pulmonary inflammation in mice is partially blocked using neutralizing Abs against JAM-C, which participates in the later steps of the leukoendothelial adhesion cascade.
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ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration.
Miao-Tzu Huang,Karen Y. Larbi,Karen Y. Larbi,Christoph Scheiermann,Christoph Scheiermann,Abigail Woodfin,Abigail Woodfin,Nicole Gerwin,Nicole Gerwin,Dorian O. Haskard,Dorian O. Haskard,Sussan Nourshargh,Sussan Nourshargh +12 more
TL;DR: The findings provide direct evidence for the involvement of ICAM-2 in neutrophil transmigration in vivo, though this role appears to be stimulus specific.
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Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro
Bristi E. Chatterjee,Simon Yona,Guglielmo Rosignoli,Rebecca E. Young,Sussan Nourshargh,Roderick J. Flower,Mauro Perretti +6 more
TL;DR: A combination of inflammatory protocols and in vitro assays are used to address the specific counter‐regulatory role of endogenous AnxA1, demonstrating its inhibitory control on PMN activation and the consequent impact on the inflamed microcirculation.