S
Svetlana Becker
Researcher at University of Tübingen
Publications - 5
Citations - 331
Svetlana Becker is an academic researcher from University of Tübingen. The author has contributed to research in topics: Proinflammatory cytokine & Mucin. The author has an hindex of 4, co-authored 5 publications receiving 251 citations. Previous affiliations of Svetlana Becker include University of Hohenheim.
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Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis.
Michael Gersemann,Svetlana Becker,Svetlana Becker,Irmgard Kübler,Maureen J. Koslowski,Guoxing Wang,Klaus Herrlinger,Joscha Griger,Joscha Griger,Peter Fritz,Klaus Fellermann,Matthias Schwab,Jan Wehkamp,Eduard F. Stange +13 more
TL;DR: Both transcription factors are key regulators of goblet cell differentiation and mucin formation in the human colon, and inflammation is associated with an enhanced gobleT cell differentiation in CD but not in UC, a defect possibly of pathogenic importance.
Journal ArticleDOI
Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD
Michael Gersemann,Michael Gersemann,Svetlana Becker,Sabine Nuding,Lena Antoni,German Ott,Peter Fritz,Naohide Oue,Wataru Yasui,Jan Wehkamp,Jan Wehkamp,Eduard F. Stange +11 more
TL;DR: OLFM4 is overexpressed in active IBD and secreted into mucus and seems to be of functional relevance in IBD as a mucus component, possibly by binding defensins.
Journal ArticleDOI
Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease.
Irmgard Kübler,Maureen J. Koslowski,Michael Gersemann,Klaus Fellermann,Julia Beisner,Svetlana Becker,K Rothfuss,Klaus Herrlinger,Eduard F. Stange,Jan Wehkamp,Jan Wehkamp +10 more
TL;DR: This data indicates that a central role of the innate immune barrier in the pathophysiology of Crohn’s Disease is suggested, and important factors providing this barrier are antimicrobial peptides like the α‐ and β‐defensins.