Journal ArticleDOI
Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis.
Michael Gersemann,Svetlana Becker,Svetlana Becker,Irmgard Kübler,Maureen J. Koslowski,Guoxing Wang,Klaus Herrlinger,Joscha Griger,Joscha Griger,Peter Fritz,Klaus Fellermann,Matthias Schwab,Jan Wehkamp,Eduard F. Stange +13 more
TLDR
Both transcription factors are key regulators of goblet cell differentiation and mucin formation in the human colon, and inflammation is associated with an enhanced gobleT cell differentiation in CD but not in UC, a defect possibly of pathogenic importance.About:
This article is published in Differentiation.The article was published on 2009-01-01. It has received 240 citations till now. The article focuses on the topics: Goblet cell & Mucin.read more
Citations
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Journal ArticleDOI
Homeostasis and Inflammation in the Intestine
TL;DR: This Review considers the many cellular and molecular methods by which inflammatory responses are regulated to maintain intestinal homeostasis and the disease states that can ensue when this balance is lost.
Journal ArticleDOI
Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent.
Laura Wrzosek,Sylvie Miquel,Marie-Louise Noordine,Stephan Bouet,Stephan Bouet,Marie Joncquel Chevalier-Curt,Marie Joncquel Chevalier-Curt,Véronique Robert,Catherine Philippe,Chantal Bridonneau,Claire Cherbuy,Catherine Robbe-Masselot,Catherine Robbe-Masselot,Philippe Langella,Muriel Thomas +14 more
TL;DR: The importance of the balance between two main commensal bacteria in maintaining colonic epithelial homeostasis via their respective effects on mucus is revealed via the influence of B. thetaiotaomicron and F. prausnitzii.
Journal ArticleDOI
Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis.
Roni Nowarski,Ruaidhri Jackson,Nicola Gagliani,Marcel R. de Zoete,Noah W. Palm,Will Bailis,Jun Siong Low,Christian C. D. Harman,Morven Graham,Eran Elinav,Richard A. Flavell,Richard A. Flavell +11 more
TL;DR: It is shown that IL-18 is critical in driving the pathologic breakdown of barrier integrity in a model of colitis, and the mechanism of goblet cell dysfunction that underlies the pathology of ulcerative colitis is informed on.
Journal ArticleDOI
Mechanisms and consequences of intestinal dysbiosis
G. Adrienne Weiss,Thierry Hennet +1 more
TL;DR: The characterization of the changes leading to intestinal dysbiosis and the identification of the microbial taxa contributing to pathological effects are essential prerequisites to better understand the impact of the microbiota on health and disease.
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Intestinal barrier in inflammatory bowel disease.
TL;DR: This review provides an overview about the major components of this protective system as for example an intact epithelium, the synthesis of various antimicrobial peptides and the formation of the mucus layer and the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease.
References
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Journal ArticleDOI
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more
TL;DR: It is suggested that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn’s disease that can now be further investigated.
Journal ArticleDOI
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Yasunori Ogura,Denise K. Bonen,Naohiro Inohara,Dan L. Nicolae,Felicia F. Chen,Richard Ramos,Heidi M. Britton,Thomas M. Moran,Reda Karaliuskas,Richard H. Duerr,Jean-Paul Achkar,Steven R. Brant,Theodore M. Bayless,Barbara S. Kirschner,Stephen B. Hanauer,Gabriel Núñez,Judy H. Cho +16 more
TL;DR: It is shown that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease, and a link between an innate immune response to bacterial components and development of disease is suggested.
Journal ArticleDOI
Unravelling the pathogenesis of inflammatory bowel disease
TL;DR: Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation as mentioned in this paper, which have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis.
Journal ArticleDOI
Mucosal flora in inflammatory bowel disease
Alexander Swidsinski,Axel Ladhoff,Annelie Pernthaler,Sonja Swidsinski,Vera Loening-Baucke,Marianne Ortner,Jutta Weber,Uwe Hoffmann,Stefan Schreiber,Manfred Dietel,Herbert Lochs +10 more
TL;DR: It is hypothesized that the healthy mucosa is capable of holding back fecal bacteria and that this function is profoundly disturbed in patients with IBD, suggesting that the changes in the mucosal flora in IBD are not secondary to inflammation, but a result of a specific host response.
Journal ArticleDOI
The fundamental basis of inflammatory bowel disease
TL;DR: It is concluded that IBD is indeed characterized by an abnormal mucosal immune response but that microbial factors and epithelial cell abnormalities can facilitate this response.