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Swapna V. Shenvi

Researcher at Children's Hospital Oakland Research Institute

Publications -  16
Citations -  1659

Swapna V. Shenvi is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: Glutathione & Gene expression. The author has an hindex of 11, co-authored 15 publications receiving 1527 citations. Previous affiliations of Swapna V. Shenvi include Oregon State University.

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Journal ArticleDOI

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

Jung H. Suh, +6 more
- 09 Mar 2004 - 
TL;DR: The age-related loss in GSH synthesis may be caused by dysregulation of ARE-mediated gene expression, but chemoprotective agents, like LA, can attenuate this loss.
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Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.

Anthony R. Smith, +4 more
- 01 May 2004 - 
TL;DR: The known biochemical properties of alpha-Lipoic acid are reviewed with particular reference to how LA may be an effective agent to ameliorate certain pathophysiologies of many chronic diseases.
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Glutathione Metabolism during Aging and in Alzheimer Disease

Honglei Liu, +4 more
- 01 Jun 2004 - 
TL;DR: The results suggest that GCL plays a critical role in maintaining GSH homeostasis under both physiological and pathological conditions; decreased GSH content may be involved in AD pathology in humans; and estrogen increases G SH content in mice by multiple mechanisms.
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Gender differences in glutathione metabolism in Alzheimer's disease

Honglei Liu, +4 more
- 15 Mar 2005 - 
TL;DR: It was shown for the first time that GSH metabolism was regulated differently in male and female AD patients, suggesting that a decreased de novo GSH synthetic capacity is responsible for the decline in GSH content in AD.
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A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations

Sarah J Zyba, +9 more
- 01 Feb 2017 - 
TL;DR: A moderate 4-mg/d increase in dietary zinc improves zinc absorption but does not alter plasma zinc, and the repair of DNA strand breaks improves, as do serum protein concentrations that are associated with the DNA repair process.