The c2d Spitzer Legacy project obtained images and photometry with both IRAC and MIPS instruments for five large, nearby molecular clouds. Three of the clouds were also mapped in dust continuum emission at 1.1 mm, and optical spectroscopy has been obtained for some clouds. This paper combines information drawn from studies of individual clouds into a combined and updated statistical analysis of star-formation rates and efficiencies, numbers and lifetimes for spectral energy distribution (SED) classes, and clustering properties. Current star-formation efficiencies range from 3% to 6%; if star formation continues at current rates for 10 Myr, efficiencies could reach 15-30%. Star-formation rates and rates per unit area vary from cloud to cloud; taken together, the five clouds are producing about 260 M ☉ of stars per Myr. The star-formation surface density is more than an order of magnitude larger than would be predicted from the Kennicutt relation used in extragalactic studies, reflecting the fact that those relations apply to larger scales, where more diffuse matter is included in the gas surface density. Measured against the dense gas probed by the maps of dust continuum emission, the efficiencies are much higher, with stellar masses similar to masses of dense gas, and the current stock of dense cores would be exhausted in 1.8 Myr on average. Nonetheless, star formation is still slow compared to that expected in a free-fall time, even in the dense cores. The derived lifetime for the Class I phase is 0.54 Myr, considerably longer than some estimates. Similarly, the lifetime for the Class 0 SED class, 0.16 Myr, with the notable exception of the Ophiuchus cloud, is longer than early estimates. If photometry is corrected for estimated extinction before calculating class indicators, the lifetimes drop to 0.44 Myr for Class I and to 0.10 for Class 0. These lifetimes assume a continuous flow through the Class II phase and should be considered median lifetimes or half-lives. Star formation is highly concentrated to regions of high extinction, and the youngest objects are very strongly associated with dense cores. The great majority (90%) of young stars lie within loose clusters with at least 35 members and a stellar density of 1 M ☉ pc–3. Accretion at the sound speed from an isothermal sphere over the lifetime derived for the Class I phase could build a star of about 0.25 M ☉, given an efficiency of 0.3. Building larger mass stars by using higher mass accretion rates could be problematic, as our data confirm and aggravate the "luminosity problem" for protostars. At a given T bol, the values for L bol are mostly less than predicted by standard infall models and scatter over several orders of magnitude. These results strongly suggest that accretion is time variable, with prolonged periods of very low accretion. Based on a very simple model and this sample of sources, half the mass of a star would be accreted during only 7% of the Class I lifetime, as represented by the eight most luminous objects.

/pdf/the-spitzer-c2d-legacy-results-star-formation-rates-and-5ddczd4myk.pdf

The Spitzer c2d legacy results: star-formation rates and efficiencies; evolution and lifetimes

Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. In addition, over one hundred clinical studies have been carried out with curcumin. One of the major problems with curcumin is perceived to be the bioavailability. How curcumin should be delivered in vivo, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review. Various formulations of curcumin that are currently available are also discussed.

http://www.e-crt.org/upload/pdf/crt-46-2.pdf

Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden spice

Searching for planets around stars with different masses helps us to assess the outcome of planetary formation for different initial conditions. The low-mass M dwarfs are also the most frequent stars in our Galaxy and potentially therefore, the most frequent planet hosts. Aims. We present observations of 102 southern nearby M dwarfs, using a fraction of our guaranteed time on the ESO/HARPS spectrograph. We observed for 460 h and gathered 1965 precise (~1-3 m/s) radial velocities (RVs), spanning the period from Feb. 11, 2003 to Apr. 1, 2009. Methods. For each star observed, we derive a time series and its precision as well as its variability. We apply systematic searches for long-term trends, periodic signals, and Keplerian orbits (from one to four planets). We analyze the subset of stars with detected signals and apply several diagnostics to discriminate whether the observed Doppler shifts are caused by either stellar surface inhomogeneities or the radial pull of orbiting planets. To prepare for the statistical view of our survey, we also compute the limits on possible unseen signals, and derive a first estimate of the frequency of planets orbiting M dwarfs. Results. We recover the planetary signals of 9 planets announced by our group (Gl 176 b, Gl 581 b, c, d & e, Gl 674 b, Gl 433 b, Gl 667C b, and Gl 667C c). We present radial velocities confirming that GJ 849 hosts a Jupiter-mass planet, plus a long-term radial-velocity variation. We also present RVs that precise the planetary mass and period of Gl 832b. We detect long-term RV changes for Gl 367, Gl 680, and Gl 880, which are indicative of yet unknown long-period companions. We identify candidate signals in the radial-velocity time series of 11 other M dwarfs. Spectral diagnostics and/or photometric observations demonstrate however that these signals are most probably caused by stellar surface inhomogeneities. Finally, we find that our survey is sensitive to a few Earth-mass planets for periods up to several hundred days. We derive a first estimate of the occurrence of M-dwarf planets as a function of their minimum mass and orbital period. In particular, we find that giant planets (msini = 100 − 1000 M⊕) have a low frequency (e.g. f ≲ 1% for P = 1 − 10 d and f = 0.02+0.03-0.01 for P = 10 − 100 d), whereas super-Earths (msini = 1 − 10 M⊕) are likely very abundant (f = 0.36+0.25-0.10 for P = 1 − 10 d and f = 0.52+0.50-0.16 for P = 10 − 100 d). We also obtained η⊕ = 0.41+0.54-0.13, which is the frequency of habitable planets orbiting M dwarfs (1 ≤ msini ≤ 10 M⊕). For the first time, η⊕ is a direct measure and not a number extrapolated from the statistics of more massive and/or shorter-period planets.

/pdf/the-harps-search-for-southern-extra-solar-planets-xxxi-the-m-4u6wk3ry13.pdf

The HARPS search for southern extra-solar planets - XXXI. The M-dwarf sample

Curcumin nanoformulations : A review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment

Context. AKARI is the first Japanese astronomical satellite dedicated to infrared astronomy. One of the main purposes of AKARI is the all-sky survey performed with six infrared bands between 9 μ m and 200 μ m during the period from 2006 May 6 to 2007 August 28. In this paper, we present the mid-infrared part (9 μ m and 18 μ m bands) of the survey carried out with one of the on-board instruments, the infrared camera (IRC).Aims. We present unprecedented observational results of the 9 μ m and 18 μ m AKARI all-sky survey and detail the operation and data processing leading to the point source detection and measurements.Methods. The raw data are processed to produce small images for every scan, and the point sources candidates are derived above the 5σ  noise level per single scan. The celestial coordinates and fluxes of the events are determined statistically and the reliability of their detections is secured through multiple detections of the same source within milli-seconds, hours, and months from each other.Results. The sky coverage is more than 90% for both bands. A total of 877 091 sources (851 189 for 9 μ m, 195 893 for 18 μ m) are confirmed and included in the current release of the point source catalog. The detection limit for point sources is 50 mJy and 90 mJy for the 9 μ m and 18 μ m bands, respectively. The position accuracy is estimated to be better than 2'' . Uncertainties in the in-flight absolute flux calibration are estimated to be 3% for the 9 μ m band and 4% for the 18 μ m band. The coordinates and fluxes of detected sources in this survey are also compared with those of the IRAS survey and are found to be statistically consistent.

/pdf/the-akari-irc-mid-infrared-all-sky-survey-2n63kvzb4t.pdf

The AKARI/IRC mid-infrared all-sky survey

The IRSA 2MASS all-sky point source catalog

Nanocapsulated curcumin: Oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat

The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat.

Quercetin in vesicular delivery systems: Evaluation in combating arsenic-induced acute liver toxicity associated gene expression in rat model

Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress.

Swarupa Ghosh

Papers

The IRSA 2MASS all-sky point source catalog

Nanocapsulated curcumin: Oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat

The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat.

Quercetin in vesicular delivery systems: Evaluation in combating arsenic-induced acute liver toxicity associated gene expression in rat model

Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress.