S
Syam Nair
Researcher at University of Gothenburg
Publications - 25
Citations - 781
Syam Nair is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Neuroprotection & Inflammation. The author has an hindex of 12, co-authored 21 publications receiving 512 citations. Previous affiliations of Syam Nair include National Institute of Technology Calicut.
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Journal ArticleDOI
Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo
Syam Nair,Kristina Sobotka,Pooja Joshi,Pierre Gressens,Pierre Gressens,Bobbi Fleiss,Bobbi Fleiss,Bobbi Fleiss,Claire Thornton,Carina Mallard,Henrik Hagberg,Henrik Hagberg +11 more
TL;DR: The data show that the activation of microglia to a classically pro‐inflammatory state is associated with a switch to glycolysis that is mediated by mitochondrial fission, a process which may be a pharmacological target for immunomodulation.
Journal ArticleDOI
Cell Death in the Developing Brain after Hypoxia-Ischemia
Claire Thornton,Bryan Leaw,Carina Mallard,Syam Nair,Masako Jinnai,Henrik Hagberg,Henrik Hagberg +6 more
TL;DR: The aim of this review is update on what cell death mechanisms that are operating particularly in the setting of the developing CNS, and the provision of alternative routes through which the cell undergoes death has to be taken into account in the hunt for novel brain protective strategies.
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Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury.
Nina Hellström Erkenstam,Peter L. P. Smith,Bobbi Fleiss,Bobbi Fleiss,Syam Nair,Pernilla Svedin,Wei Wang,Martina Boström,Pierre Gressens,Pierre Gressens,Henrik Hagberg,Henrik Hagberg,Kelly L. Brown,Karin Sävman,Carina Mallard +14 more
TL;DR: HI was characterized by an early mixed gene response, but with a large expansion of mainly the CD86 positive population during the first day, suggesting a novel role in cell infiltration and immunomodulation for this cell population after neonatal injury.
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Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury.
Claire Thornton,Adam Jones,Syam Nair,Afra Aabdien,Carina Mallard,Henrik Hagberg,Henrik Hagberg +6 more
TL;DR: Mitoprotective therapies may offer a new avenue of intervention for babies who suffer lifelong disabilities due to birth asphyxia, and act as a focal point in injury development in the immature brain.
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Computational identification of novel histone deacetylase inhibitors by docking based QSAR
TL;DR: Six compounds with good absorption, distribution, metabolism, and excretion (ADME) properties were selected as potential HDAC inhibitors and the molecular interactions of these inhibitors with the HDAC active site residues were discussed in detail.