S
Syed Muhammad Kashif
Researcher at University of Sindh
Publications - 16
Citations - 551
Syed Muhammad Kashif is an academic researcher from University of Sindh. The author has contributed to research in topics: Docking (molecular) & Internal medicine. The author has an hindex of 12, co-authored 13 publications receiving 448 citations.
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Journal ArticleDOI
Synthesis of novel flavone hydrazones: in-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies.
Syahrul Imran,Muhammad Taha,Nor Hadiani Ismail,Syed Muhammad Kashif,Fazal Rahim,Waqas Jamil,Maywan Hariono,Muhammad Yusuf,Habibah A. Wahab +8 more
TL;DR: Increase in activity observed for compounds 2 to 34 clearly highlights the importance of flavone, hydrazide and hydrazone linkage in suppressing the activity of α-glucosidase.
Journal ArticleDOI
Synthesis of novel derivatives of 4-methylbenzimidazole and evaluation of their biological activities.
Muhammad Taha,Nor Hadiani Ismail,Waqas Jamil,Hesham Rashwan,Syed Muhammad Kashif,Amyra Amat Sain,Mohd Ilham Adenan,El Hassane Anouar,Muhammad Ali,Fazal Rahim,Khalid Mohammed Khan +10 more
TL;DR: 4-Methylbenzimidazole 1-28 novel derivatives were synthesized and evaluated for their antiglycation and antioxidant activities and were found to be nontoxic to THP-1 cells.
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Synthesis, In vitro and Docking Studies of New Flavone Ethers as α-Glucosidase Inhibitors.
Syahrul Imran,Muhammad Taha,Nor Hadiani Ismail,Syed Muhammad Kashif,Fazal Rahim,Waqas Jamil,Habibah A. Wahab,Khalid Mohammed Khan +7 more
TL;DR: Docking studies for compound 7 suggest that both trifluoromethyl substituents are well positioned in a binding pocket surrounded by Phe300, Phe177, P he157, Ala278, Asp68, Tyr71 and Asp214, which is extremely significant as they are found to be important for substrates recognition by α‐glucosidase.
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Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones.
Muhammad Taha,Nor Hadiani Ismail,Waqas Jamil,Sammer Yousuf,Faridahanim Mohd Jaafar,M. I. Md Ali,Syed Muhammad Kashif,Ejaz Hussain +7 more
TL;DR: 2, 4-Dimethylbenzoylhydrazones 1–30 were synthesized by condensation reactions of 2,4-dimethylbenZoylHydrazide with various aromatic aldehydes and characterized, showing varying degree of scavenging activity toward DPPH radical with IC50 values between 25.6–190 µM.
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Synthesis, Crystal Structure, DFT Studies and Evaluation of the Antioxidant Activity of 3,4-Dimethoxybenzenamine Schiff Bases
Ahmad Nazif Aziz,Muhammad Taha,Nor Hadiani Ismail,El Hassane Anouar,Sammer Yousuf,Waqas Jamil,Khalijah Awang,Norizan Ahmat,Khalid Mohammed Khan,Syed Muhammad Kashif +9 more
TL;DR: The Schiff bases of 3,4-dimethoxybenzenamine 1–25 were synthesized and evaluated for their antioxidant activity and showed good DPPH scavenging activity and for the superoxide anion radical assay, compounds 1–3 showed better activity than the standard.