S
Sammer Yousuf
Researcher at University of Karachi
Publications - 217
Citations - 2055
Sammer Yousuf is an academic researcher from University of Karachi. The author has contributed to research in topics: Ring (chemistry) & Chemistry. The author has an hindex of 21, co-authored 191 publications receiving 1519 citations. Previous affiliations of Sammer Yousuf include Universiti Sains Malaysia.
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Journal ArticleDOI
Cholinesterase inhibiting withanolides from Withania somnifera.
TL;DR: A total of two new and four known withanolides were isolated from the whole plant of Withania somnifera and only compounds 3, 4, and 6 were found to be active against acetylcholinesterase.
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Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties.
M. Iqbal Choudhary,Sarfraz Ahmad Nawaz,Zaheer-ul-Haq,M. Arif Lodhi,M. Nabeel Ghayur,Saima Jalil,Naheed Riaz,Sammer Yousuf,Abdul Malik,Anwarul Hassan Gilani,Atta-ur-Rahman +10 more
TL;DR: The cholinesterase inhibitory potential along with calcium antagonistic ability and safe profile in human neutrophil viability assay could make compounds 1-5 possible drug candidates for further study to treat Alzheimer's disease and associated problems.
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Synthesis crystal structure of 2-methoxybenzoylhydrazones and evaluation of their α -glucosidase and urease inhibition potential
Muhammad Taha,Nor Hadiani Ismail,Mohd Syukri Baharudin,Salima Lalani,Sadia Mehboob,Khalid Mohammed Khan,Sammer Yousuf,Salman Siddiqui,Fazal Rahim,M. Iqbal Choudhary +9 more
TL;DR: In this article, the α-glucosidase inhibition with IC50 values ranging between 187 and 420μM was investigated with compounds 1, 2, 3, 6, 8, 12, and 4.
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Synthesis, reactions and biological activity of some new bis-heterocyclic ring compounds containing sulphur atom
Yahia N. Mabkhot,Assem Barakat,Assem Barakat,Abdullah Mohammed Al-Majid,Saeed Alshahrani,Sammer Yousuf,M. Iqbal Choudhary,M. Iqbal Choudhary +7 more
TL;DR: These new derivatives of thieno[2,3-b]thiophene belong to a significant category of heterocyclic compounds, which have shown a wide spectrum of medical and industrial application and were evaluated for anti-cancer activity against PC-3 cell lines, in vitro antioxidant potential and β-glucuronidase and α- glucosidase inhibitory activities.
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Zwitterionic pyrimidinium adducts as antioxidants with therapeutic potential as nitric oxide scavenger
Assem Barakat,Assem Barakat,Abdullah Mohammed Al-Majid,Hany J. Al-Najjar,Yahia N. Mabkhot,Sumaira Javaid,Sammer Yousuf,M. Iqbal Choudhary,M. Iqbal Choudhary +8 more
TL;DR: In vitro evaluation for the antioxidant activities were carried out towards the inhibition of nitric oxide (NO) radical, known to regulate a mechanism of signals for various cellular functions.