H
Harikrishna Nakshatri
Researcher at Indiana University
Publications - 241
Citations - 16513
Harikrishna Nakshatri is an academic researcher from Indiana University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 63, co-authored 218 publications receiving 15268 citations. Previous affiliations of Harikrishna Nakshatri include Indiana University – Purdue University Indianapolis & Veterans Health Administration.
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Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently
Mark Leid,Mark Leid,Philippe Kastner,Philippe Kastner,Ruth Lyons,Ruth Lyons,Harikrishna Nakshatri,Harikrishna Nakshatri,Michael Saunders,Michael Saunders,Tim Zacharewski,Tim Zacharewski,Jia Yang Chen,Jia Yang Chen,Adrien Staub,Adrien Staub,Jean Marie Garnier,Jean Marie Garnier,Sylvie Mader,Sylvie Mader,Pierre Chambon,Pierre Chambon +21 more
TL;DR: It is shown that unstable RAR-RXR heterodimers were formed in solution, and that C-terminal sequences and the DNA-binding domains of both receptors were required for efficient formation of stable heterodIMers on response elements.
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CD44 + /CD24 - breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis
Carol Sheridan,Hiromitsu Kishimoto,Robyn K. Fuchs,Sanjana Mehrotra,Poornima Bhat-Nakshatri,Charles H. Turner,Robert J. Goulet,Sunil Badve,Harikrishna Nakshatri +8 more
TL;DR: Breast cancer cells with CD44+/CD24- subpopulation express higher levels of proinvasive genes and have highly invasive properties, however, this phenotype is not sufficient to predict capacity for pulmonary metastasis.
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Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
Robert Campbell,Poornima Bhat-Nakshatri,Nikhil M. Patel,Demetra Constantinidou,Simak Ali,Harikrishna Nakshatri +5 more
TL;DR: A molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERα, and inhibition of tamoxifen-induced apoptotic regression is defined.
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Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth.
Harikrishna Nakshatri,Poornima Bhat-Nakshatri,Daniel A. Martin,Robert J. Goulet,George W. Sledge +4 more
TL;DR: Since ER inhibits the constitutive as well as inducible activation function of NF-kappaB in a dose-dependent manner, it is proposed that breast cancers that lack functional ER overexpress NF- kappaB-regulated genes.
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NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4
Gregory M. Helbig,Kent W. Christopherson,Poornima Bhat-Nakshatri,Suresh M. Kumar,Hiromitsu Kishimoto,Kathy D. Miller,Hal E. Broxmeyer,Harikrishna Nakshatri +7 more
TL;DR: It is demonstrated that NF-κB regulates the motility of breast cancer cells by directly up-regulating the expression of CXCR4 and the SDF-1α-mediated migration is observed with cancer cells that metastasized to the lungs.