T
T. Le Chevalier
Researcher at Institut Gustave Roussy
Publications - 175
Citations - 9720
T. Le Chevalier is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Lung cancer & Chemotherapy. The author has an hindex of 46, co-authored 175 publications receiving 9370 citations. Previous affiliations of T. Le Chevalier include Université Paris-Saclay.
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Journal ArticleDOI
Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: results of a European multicenter trial including 612 patients.
T. Le Chevalier,D. Brisgand,Jean-Yves Douillard,J.L. Pujol,Vicente Alberola,A. Monnier,A. Riviere,Lianes P,P. Chomy,S. Cigolari +9 more
TL;DR: Since the results have demonstrated that NVB-P yields a longer survival duration and a higher response rate than VDS-P or NVB alone, with acceptable toxicity, this combination should be considered a relevant regimen in advanced NSCLC.
Journal ArticleDOI
Radiotherapy Alone Versus Combined Chemotherapy and Radiotherapy in Nonresectable Non-Small-Cell Lung Cancer: First Analysis of a Randomized Trial in 353 Patients
T. Le Chevalier,Rodrigo Arriagada,E. Quoix,Pierre Ruffié,M. Martin,M. Tarayre,Marie-José Lacombe-Terrier,Jean-Yves Douillard,Agnès Laplanche +8 more
TL;DR: The results observed in a large, randomized study that compared the effects of radiotherapy alone (the standard therapy) with those of a combination of radi therapy and chemotherapy in nonresectable squamous cell and large-cell lung carcinoma showed local control was poor in both groups and remained the major problem.
Journal ArticleDOI
Prophylactic Cranial Irradiation for Patients With Small-Cell Lung Cancer in Complete Remission
Rodrigo Arriagada,T. Le Chevalier,F Borie,A. Riviere,P. Chomy,Isabelle Monnet,A Tardivon,F Viader,M. Tarayre,Simone Benhamou +9 more
TL;DR: Prophylactic cranial irradiation given to patients with small-cell lung cancer in complete remission decreases the risk of brain metastasis threefold without a significant increase in complications.
Journal ArticleDOI
Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: A systematic review and meta-analysis of individual patient data from 16 randomized controlled trials
Sarah Burdett,S. Burdett,Richard Stephens,Lesley A. Stewart,Jayne F. Tierney,A. Auperin,T. Le Chevalier,C. Le Pechoux,Jean-Pierre Pignon,Rodrigo Arriagada,Rodrigo Arriagada,Julian P T Higgins,David P. Johnson,J. Van Meerbeeck,M. K. B. Parmar,R. Souhami,David R. Bell,G. Cartei,Yvon Cormier,Michael Cullen,Patricia A. Ganz,C. Gridelli,Stein Kaasa,E. Quoix,E. Rapp,Lesley Seymour,Stephen G. Spiro,Nick Thatcher,D. Tummarello,Chris Williams,I. Williamson +30 more
TL;DR: In this article, an individual patient data meta-analysis of supportive care and chemotherapy for non-small-cell lung cancer (NSCLC) was carried out to assess newer regimens and determine conclusively the effect of chemotherapy.
Journal ArticleDOI
Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data.
Rodrigo Arriagada,A. Auperin,S Burdett,Julian P T Higgins,David H. Johnson,T. Le Chevalier,C. Le Pechoux,M K B Parmar,J.P. Pignon,Robert L. Souhami,Richard Stephens,Lesley A. Stewart,Jayne F. Tierney,Hélène Tribodet,J. Van Meerbeeck +14 more
TL;DR: The addition of adjuvant chemotherapy after surgery for patients with operable non-small-cell lung cancer improves survival, irrespective of whether chemotherapy was adjuant to surgery alone or to surgery plus radiotherapy.