Tae-Boo Choe

TL;DR: It is shown that activating transcription factor 4 (ATF4) and CCAAT/enhancer-binding protein-beta (C/EBP-beta) negatively regulate mTOR via Redd1 expression in response to oxidative and ER stress, and the Redd1 gene is transactivated by the ATF4 and C/E BP family of transcription factors, leading to mTOR inhibition in response.

TL;DR: The results demonstrate that hypoxic condition-and HCD-induced expression of Redd1 is mediated by coactivation of Sp1 and HIF-1alpha downstream of the PI3K/Akt signaling pathway.

TL;DR: The activation of PKC by PMA in these cells plays a critical role in the regulation of MMPs/TIMPs system, which has a major role in tumor invasion and metastasis.

TL;DR: It is demonstrated that a combination of sulindac and arsenic trioxide (ATO) induces more extensive apoptosis than either drug alone in A549 human non-small cell lung carcinoma (NSCLC) cells.

TL;DR: It is shown that HDACIs (including suberoylanilide hydroxamic acid and trichostatin A) and IR synergistically trigger cell death in human non-small cell lung cancer cells and the degree of radiosensitization by HDAC is influenced by acetyl p53-mediated c-myc down-regulation.