Chang-Hun Rhee

TL;DR: It is shown that activating transcription factor 4 (ATF4) and CCAAT/enhancer-binding protein-beta (C/EBP-beta) negatively regulate mTOR via Redd1 expression in response to oxidative and ER stress, and the Redd1 gene is transactivated by the ATF4 and C/E BP family of transcription factors, leading to mTOR inhibition in response.

TL;DR: The results demonstrate that hypoxic condition-and HCD-induced expression of Redd1 is mediated by coactivation of Sp1 and HIF-1alpha downstream of the PI3K/Akt signaling pathway.

TL;DR: RRC showed a higher radioresistance than the parent cell line as measured by clonogenic survival assay and showed delayed G2/M arrest, and cross-resistance to chemotherapeutic agent in RRC might be due to the highly coordinated activation of antioxidant enzymes rather than a single enzyme alone.

TL;DR: Evidence is provided that down‐regulation of Akt pathway and MMP‐2 may be one of the mechanisms by which sulindac and its metabolites inhibit glioblastoma cell invasion.

TL;DR: The results suggest that NO activates an apoptotic cascade, involving sustained JNK activation, AP‐1 DNA binding activity, and subsequent Bak and Bim induction, followed by cytochrome c and AIF releases and caspases cascade activation, resulting in human malignant brain tumor cell death.