Sungkwan An

TL;DR: Novel evidence is provided that autophagy is critically involved in malignant transformation by oncogenic K-Ras and shows that reactive oxygen species-mediated JNK activation plays a causal role in Autophagy induction through up-regulation of ATG5 and ATG7.

TL;DR: The profile of miRNA expression following IR in the human lung carcinoma cell line A549 is investigated, and the expression profiles of IR-responsive miRNAs were confirmed by qRT-PCR, suggesting that mi RNA expression is affected by radiation, and they may be involved in the regulation of radiation responses.

TL;DR: It is shown that activating transcription factor 4 (ATF4) and CCAAT/enhancer-binding protein-beta (C/EBP-beta) negatively regulate mTOR via Redd1 expression in response to oxidative and ER stress, and the Redd1 gene is transactivated by the ATF4 and C/E BP family of transcription factors, leading to mTOR inhibition in response.

TL;DR: The results demonstrate that hypoxic condition-and HCD-induced expression of Redd1 is mediated by coactivation of Sp1 and HIF-1alpha downstream of the PI3K/Akt signaling pathway.

TL;DR: It is demonstrated that resveratrol treatment altered miRNA expression in A549 cells, and target genes related to apoptosis, cell cycle regulation, cell proliferation, and differentiation are identified using a miRNA target-prediction program.