T
Takahiro Tougan
Researcher at Osaka University
Publications - 59
Citations - 1724
Takahiro Tougan is an academic researcher from Osaka University. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 21, co-authored 54 publications receiving 1511 citations.
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Journal ArticleDOI
Direct Metagenomic Detection of Viral Pathogens in Nasal and Fecal Specimens Using an Unbiased High-Throughput Sequencing Approach
Shota Nakamura,Cheng-Song Yang,Naomi Sakon,Mayo Ueda,Takahiro Tougan,Akifumi Yamashita,Naohisa Goto,Kazuo Takahashi,Teruo Yasunaga,Kazuyoshi Ikuta,Tetsuya Mizutani,Yoshiko Okamoto,Michihira Tagami,Ryoji Morita,Norihiro Maeda,Jun Kawai,Yoshihide Hayashizaki,Yoshiyuki Nagai,Toshihiro Horii,Tetsuya Iida,Takaaki Nakaya +20 more
TL;DR: The results suggest that the unbiased high-throughput sequencing approach is useful for directly detecting pathogenic viruses without advance genetic information, and could be useful for the earlier discovery of novel emerging viruses and bioterrorism, which are difficult to detect with conventional procedures.
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Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade
Shin-Ichiro Tachibana,Steven A. Sullivan,Satoru Kawai,Shota Nakamura,Hyunjae R. Kim,Naohisa Goto,Nobuko Arisue,Nirianne Marie Q. Palacpac,Hajime Honma,Masanori Yagi,Takahiro Tougan,Yuko Katakai,Osamu Kaneko,Toshihiro Mita,Kiyoshi Kita,Yasuhiro Yasutomi,Patrick L. Sutton,Rimma Shakhbatyan,Toshihiro Horii,Teruo Yasunaga,John W. Barnwell,Ananias A. Escalante,Jane M. Carlton,Kazuyuki Tanabe +23 more
TL;DR: It is shown that genomes of the monkey malaria clade can be characterized by copy-number variants (CNVs) in multigene families involved in evasion of the human immune system and invasion of host erythrocytes, providing a map of genetic variation that can be used to map parasite traits and study parasite populations.
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Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.
Shohei Koyama,Shohei Koyama,Taiki Aoshi,Takeshi Tanimoto,Yutaro Kumagai,Kouji Kobiyama,Takahiro Tougan,Kazuo Sakurai,Cevayir Coban,Toshihiro Horii,Shizuo Akira,Ken Ishii +11 more
TL;DR: It is shown that plasmacytoid dendritic cells (pDCs) and type I interferon (IFN)–mediated signaling delineate the immunogenicity of live attenuated virus, inactivated whole-virus (WV), and split-Virus vaccines.
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Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza.
Kazuhiko Matsuo,Sachiko Hirobe,Yayoi Yokota,Yurika Ayabe,Masashi Seto,Ying-Shu Quan,Fumio Kamiyama,Takahiro Tougan,Toshihiro Horii,Yohei Mukai,Naoki Okada,Shinsaku Nakagawa +11 more
TL;DR: It is demonstrated that TCI using a dissolving microneedle array can elicit large immune responses against infectious diseases.
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Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients
Nobuo Nakamura,Yasunori Shimaoka,Takahiro Tougan,Hiroaki Onda,Daisuke Okuzaki,Hanjun Zhao,Azumi Fujimori,Norikazu Yabuta,Ippei Nagamori,Akie Tanigawa,Jun Sato,Takenori Oda,Kenji Hayashida,Ryuji Suzuki,Masao Yukioka,Hiroshi Nojima,Takahiro Ochi +16 more
TL;DR: The comprehensively identified genes whose expressions are augmented in bone marrow-derived mononuclear cells from patients with Rheumatoid Arthritis as compared with BMMCs from Osteoarthritis patients and named them AURA after augmented in RA, and proposed that the expression profiling of these AURA genes may improve the understanding of the pathogenesis of RA.