T
Takako Watanabe
Researcher at Tokyo Medical and Dental University
Publications - 17
Citations - 531
Takako Watanabe is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Interferon & Hepatitis C virus. The author has an hindex of 12, co-authored 17 publications receiving 473 citations.
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Journal ArticleDOI
Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein.
Yasuhiro Itsui,Naoya Sakamoto,Sei Kakinuma,Mina Nakagawa,Yuko Sekine-Osajima,Megumi Tasaka-Fujita,Yuki Nishimura-Sakurai,Gouki Suda,Yuko Karakama,Kako Mishima,Machi Yamamoto,Takako Watanabe,Mayumi Ueyama,Yusuke Funaoka,Seishin Azuma,Mamoru Watanabe +15 more
TL;DR: Binding of the HCV‐NS5B protein to GBP‐1 countered the antiviral effect by inhibition of its GTPase activity, which may contribute to resistance to innate, IFN‐mediated antiviral defense and to the clinical persistence of HCV infection.
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Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features
Fukiko Kawai-Kitahata,Yasuhiro Asahina,Shinji Tanaka,Sei Kakinuma,Miyako Murakawa,Sayuri Nitta,Takako Watanabe,Satoshi Otani,Miki Taniguchi,Fumio Goto,Hiroko Nagata,Shun Kaneko,Megumi Tasaka-Fujita,Yuki Nishimura-Sakurai,Seishin Azuma,Yasuhiro Itsui,Mina Nakagawa,Minoru Tanabe,Shinichi Takano,Mitsuharu Fukasawa,Minoru Sakamoto,Shinya Maekawa,Nobuyuki Enomoto,Mamoru Watanabe +23 more
TL;DR: Gene alterations in Tert promoter, TP53, CTNNB1, and HBV integration were closely associated with HCC development, and mutations in TERT promoter are related to poor prognosis.
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Analysis of Interferon Signaling by Infectious Hepatitis C Virus Clones with Substitutions of Core Amino Acids 70 and 91
Yusuke Funaoka,Naoya Sakamoto,Goki Suda,Yasuhiro Itsui,Mina Nakagawa,Sei Kakinuma,Takako Watanabe,Kako Mishima,Mayumi Ueyama,Izumi Onozuka,Sayuri Nitta,Akiko Kitazume,Kei Kiyohashi,Miyako Murakawa,Seishin Azuma,Kiichiro Tsuchiya,Mamoru Watanabe +16 more
TL;DR: It is shown that HCV R70 and L91 core mutants were resistant to interferon in vitro, and the resistance may be induced by IL-6-induced upregulation of SOCS3, and those mechanisms may explain clinicalinterferon resistance of HCV core mutants.
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Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice
Izumi Onozuka,Sei Kakinuma,Akihide Kamiya,Masato Miyoshi,Naoya Sakamoto,Kei Kiyohashi,Takako Watanabe,Yusuke Funaoka,Mayumi Ueyama,Mina Nakagawa,Naohiko Koshikawa,Motoharu Seiki,Hiromitsu Nakauchi,Mamoru Watanabe +13 more
TL;DR: It is suggested that MMP-2 suppresses tissue inhibitor of metalloproteinase 1 up-regulation during liver fibrosis, and that myofibroblastic change of hepatic stellate cells was promoted in M MP-2 deficient liver.
Journal ArticleDOI
An inverse relationship between autoimmune liver diseases and Strongyloides stercoralis infection.
Hajime Aoyama,Tetsuo Hirata,Hiroshi Sakugawa,Takako Watanabe,Satoru Miyagi,Tatsuji Maeshiro,Takayuki Chinen,M Kawane,Osamu Zaha,Tomokuni Nakayoshi,Fukunori Kinjo,Jiro Fujita +11 more
TL;DR: It is hypothesized that immunomodulation by S. stercoralis infection may lower the incidence of autoimmune liver disease and improve the prognosis for patients with autoimmune liver diseases.