T
Takamitsu Mizobe
Researcher at University of Occupational and Environmental Health Japan
Publications - 9
Citations - 165
Takamitsu Mizobe is an academic researcher from University of Occupational and Environmental Health Japan. The author has contributed to research in topics: Lymphoma & Receptor tyrosine kinase. The author has an hindex of 6, co-authored 9 publications receiving 158 citations.
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Intracellular galectin-9 activates inflammatory cytokines in monocytes
Ai Matsuura,Junichi Tsukada,Takamitsu Mizobe,Takehiro Higashi,Fumihiko Mouri,Rena Tanikawa,Akira Yamauchi,Mitsuomi Hirashima,Yoshiya Tanaka +8 more
TL;DR: The results indicate that galectin‐9 is a LPS‐responsive factor, and demonstrate that intracellular galectIn‐9 transactivates inflammatory cytokine genes in monocytes through direct physical interaction with NF‐IL6.
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Imatinib mesylate‐sensitive blast crisis immediately after discontinuation of imatinib mesylate therapy in chronic myelogenous leukemia: Report of two cases
Takehiro Higashi,Junichi Tsukada,Chiaki Kato,Atsushi Iwashige,Takamitsu Mizobe,Shinichiro Machida,Hiroaki Morimoto,Ryosuke Ogawa,Yoko Toda,Yoshiya Tanaka +9 more
TL;DR: The report suggests the possibility that withdrawal of imatinib mesylate may lead to proliferation of blast clones even in patients showing good responses to Imatinib Mesylate without signs of disease progression, as reported in two CML patients.
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Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1.
Fumihiko Mouri,Junichi Tsukada,Takamitsu Mizobe,Takehiro Higashi,Yasuhiro Yoshida,Yasuhiro Minami,Hiroto Izumi,Yoshihiko Kominato,Kimitoshi Kohno,Yoshiya Tanaka +9 more
TL;DR: It is reported that intracellular HMGB1 synergizes with a macrophage/monocyte‐specific E26 transformation‐specific sequence (Ets) transcription factor PU.1 to transactivate the promoter of the IL1B gene coding a 31‐kDa proIL‐1β protein.
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Growth suppression of human mast cells expressing constitutively active c-kit receptors by JNK inhibitor SP600125.
Bin Wang,Junichi Tsukada,Takehiro Higashi,Takamitsu Mizobe,Ai Matsuura,Fumihiko Mouri,Norifumi Sawamukai,Chisei Ra,Yoshiya Tanaka +8 more
TL;DR: The results obtained from the present study suggest the possibility that JNK/c-Jun may be a therapeutic target in diseases associated with mutations in the catalytic domain of c-kit.
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Constitutive association of MyD88 to IRAK in HTLV-I–transformed T cells
Takamitsu Mizobe,Junichi Tsukada,Takehiro Higashi,Fumihiko Mouri,Ai Matsuura,Rena Tanikawa,Yasuhiro Minami,Yasuhiro Yoshida,Yoshiya Tanaka +8 more
TL;DR: The results show a novel pathway in NF-kappaB activation in HTLV-I-transformed T cells and further demonstrate a critical role of MyD88 in their dysregulated gene activation, survival, and proliferation.