T
Takashi Akazawa
Researcher at Hokkaido University
Publications - 63
Citations - 4525
Takashi Akazawa is an academic researcher from Hokkaido University. The author has contributed to research in topics: Toll-like receptor & Immunotherapy. The author has an hindex of 30, co-authored 63 publications receiving 4209 citations.
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TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
TL;DR: This work has identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN-β promoter in response to poly(I):poly(C).
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Cell death caused by selenium deficiency and protective effect of antioxidants
TL;DR: The results suggest that the ROS, especially lipid hydroperoxides, are involved in the cell death caused by selenium deficiency and that seenium and vitamin E cooperate in the defense against oxidative stress upon cells by detoxifying and inhibiting the formation of lipid hydroPeroxides.
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Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway
Hiroaki Shime,Masahiko Yabu,Takashi Akazawa,Ken Kodama,Misako Matsumoto,Tsukasa Seya,Norimitsu Inoue +6 more
TL;DR: Lactic acid is a proinflammatory mediator that is secreted by tumor cells to activate the IL-23/IL-17 proinflammatory pathway but not the Th1 pathway, suggesting that targeting the lactic acid-induced proinflammatory response may be a useful approach for treating cancer.
A Novel Sucrose Synthase Pathway for Sucrose Degradation in
Steven C. Huber,Takashi Akazawa +1 more
TL;DR: In this paper, two pathways for sucrose degradation and glycolysis in cultured sycamore (Acer pseudoplatanus L.) cells were assayed and characterized in crude extracts and after partial purification, in an attempt to identify pathways for Sucrose catabolism.
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Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells.
Takashi Akazawa,Takashi Ebihara,Manabu Okuno,Yu Okuda,Masashi Shingai,Kunio Tsujimura,Toshitada Takahashi,Masahito Ikawa,Masaru Okabe,Norimitsu Inoue,Miki Okamoto-Tanaka,Hiroyoshi Ishizaki,Jun Miyoshi,Misako Matsumoto,Tsukasa Seya +14 more
TL;DR: It is shown that the TLR adaptor TICAM-1 (TRIF) participates in mDC-derived antitumor NK activation, resulting in the regression of low MHC-expressing tumors.