S
Saori Oka
Researcher at Teikyo University
Publications - 42
Citations - 3366
Saori Oka is an academic researcher from Teikyo University. The author has contributed to research in topics: Cannabinoid receptor & Cannabinoid. The author has an hindex of 26, co-authored 38 publications receiving 3084 citations.
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Journal ArticleDOI
Identification of GPR55 as a lysophosphatidylinositol receptor.
TL;DR: Results strongly suggest that GPR55 is a specific and functional receptor for lysophosphatidylinositol, which induced rapid phosphorylation of the extracellular signal-regulated kinase in transiently or stably GPR 55-expressing cells.
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Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance.
TL;DR: Evidence is gradually accumulating and indicates that 2-AG is the most efficacious endogenous natural ligand for the cannabinoid receptors, which is a degradation product of arachidonic acid-containing glycerophospholipid such as inositol phospholipids.
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Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand.
TL;DR: Two lines of evidence indicate that 2-AG plays an important role as a retrograde messenger molecule in the regulation of synaptic transmission and has also been shown to be involved in theregulation of various types of inflammatory reactions and immune responses.
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Synaptically Driven Endocannabinoid Release Requires Ca2+-Assisted Metabotropic Glutamate Receptor Subtype 1 to Phospholipase C β4 Signaling Cascade in the Cerebellum
Takashi Maejima,Saori Oka,Yuki Hashimotodani,Takako Ohno-Shosaku,Atsu Aiba,Dianqing Wu,Keizo Waku,Takayuki Sugiura,Masanobu Kano +8 more
TL;DR: The results strongly suggest that under physiological conditions, excitatory synaptic inputs to PCs activate the Ca2+-assisted mGluR1-PLCβ4 cascade, and thereby produce 2-AG, which retrogradely modulates synaptic transmission to PCs.
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Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms.
Atsushi Yamashita,Yasuhiro Hayashi,Yoko Nemoto-Sasaki,Makoto Ito,Saori Oka,Takashi Tanikawa,Keizo Waku,Takayuki Sugiura +7 more
TL;DR: Recent progresses in acyltransferase research including the identification of the enzyme's genes are described in this review of fatty acid remodeling systems for phospholipids.