Takashi Wada

TL;DR: A highly specific neutralizing antibody against IL‐8 was administered in several types of acute inflammatory reactions, including lipopolysaccharide‐induced dermatitis, LPS/IL‐1‐induced arthritis, lung reperfusion injury, and acute immune complex‐type glomerulonephritis to suggest thatIL‐8 plays a causative role in acute inflammation by recruiting and activating neutrophils.

TL;DR: Observations suggest that locally produced MCP-1 may be involved in the development of advanced diabetic nephropathy, especially in the formation of tubulointerstitial lesions possibly through Mphi recruitment and activation.

TL;DR: In this paper, the authors investigated renal interstitial fibrosis induced by a unilateral ureteral obstruction in CCR2 gene-targeted mice and mice treated with propagermanium or RS-504393, cCR2 inhibitors.

TL;DR: ADAMTS-1 thus appears necessary for normal growth, fertility, and organ morphology and function, and the resemblance of the renal phenotype to human ureteropelvic junction obstruction may provide a clue to the pathogenesis of this common congenital disease.

TL;DR: It is suggested that CCR7-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis.