T
Takayoshi Ubuka
Researcher at Waseda University
Publications - 109
Citations - 7709
Takayoshi Ubuka is an academic researcher from Waseda University. The author has contributed to research in topics: Gonadotropin secretion & Gonadotropin. The author has an hindex of 44, co-authored 101 publications receiving 6992 citations. Previous affiliations of Takayoshi Ubuka include Monash University Malaysia Campus & Helen Wills Neuroscience Institute.
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Journal ArticleDOI
Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals
Lance J. Kriegsfeld,Dan Feng Mei,George E. Bentley,Takayoshi Ubuka,Alex O. Mason,Kazuhiko Inoue,Kazuyoshi Ukena,Kazuyoshi Tsutsui,Rae Silver +8 more
TL;DR: The distribution of GnIH efferents to neural sites regulating reproductive behavior and neuroendocrine secretions, expression of steroid receptors in GnIh-ir nuclei, and GnI H inhibition of luteinizing hormone secretion indicate the discovery of a system regulating the mammalian reproductive axis.
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Variation in Kisspeptin and RFamide-Related Peptide (RFRP) Expression and Terminal Connections to Gonadotropin-Releasing Hormone Neurons in the Brain: A Novel Medium for Seasonal Breeding in the Sheep
Jeremy Troy Smith,Lique M. Coolen,Lance J. Kriegsfeld,Ika Puspita Sari,Mohammad R. Jaafarzadehshirazi,Matthew J Maltby,Katherine L. Bateman,Robert L. Goodman,Alan J Tilbrook,Takayoshi Ubuka,George E. Bentley,Iain J. Clarke,Michael N. Lehman +12 more
TL;DR: It is proposed that the two RFamide peptides, kisspeptin and RFRP, act in concert, with opposing effects, to regulate the activity of GnRH neurons across the seasons, leading to the annual change in fertility and the cyclical seasonal transition from nonbreeding to breeding season.
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Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats
TL;DR: The data show that stress-induced increases in adrenal GCs cause an increase in RFRP that contributes to hypothalamic suppression of reproductive function, and this novel insight into HPA-HPG interaction provides a paradigm shift for work on stress-related reproductive dysfunction and infertility.
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Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion
Iain J. Clarke,Ika Puspita Sari,Yue Qi,Jeremy Troy Smith,Helena C. Parkington,Takayoshi Ubuka,Javed Iqbal,Qun Li,Alan J Tilbrook,Kevin Morgan,Adam J. Pawson,Kazuyoshi Tsutsui,Robert P. Millar,George E. Bentley +13 more
TL;DR: Data indicate that RFRP-3 is a specific and potent mammalian gonadotropin-inhibiting hormone, and that it acts upon pituitary gonadotropic gland function to reduce GnRH-stimulated gonADotropin secretion.
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Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain
TL;DR: It is shown that melatonin originating from the pineal gland and eyes induces GnIH expression in the quail brain, the first demonstration, to the authors' knowledge, of a direct action of melatonin on neuropeptide induction in any vertebrate class.