http://depa.fquim.unam.mx/amyd/archivero/Modeling-CrusRamirezyVargasPavonyJimenezSolorzano_11276.pdf

Modeling and comparison of dissolution profiles.

Overview of membrane science and technology membrane transport theory membrane and modules concentration polarization reverse osmosis ultrafiltration microfiltration gas separation pervaporation ion exchange membrane processes - electrodialysis carrier facilitated transport medical applications of membranes other membranes processed.

Membrane Technology and Applications

A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs

Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).

Recent advances on chitosan-based micro- and nanoparticles in drug delivery.

Results obtained from studies on the dependency on compressional force of various physical properties of compressed tablets are shown to be in good qualitative agreement with those found in an earlier investigation on sulfathiazole tablets. Such differences in behavior of several granulations as were found could be attributed mainly to the difference in relative hardness and cohesive properties of the substances employed.

The Physics of Tablet Compression: V. Studies on Aspirin, Lactose, Lactose-Aspirin, and Sulfadiazine Tablets

Ion pair extraction of pharmaceutical amines. Role of dipolar solvating agents in extraction of dextromethorphan.

Plastic electrodes specific for organic ions

This investigation is a continuation of previous studies made on the complexing behavior of caffeine with numerous pharmaceuticals. By means of solubility analysis it is shown that one-to-one complexes are formed between the xanthine and the pharmaceuticals listed under the title. The barbiturates appear to form both one-to-one and two-to-one complexes. The stability constants of the several complexes have also been estimated.

Investigation of some complexes formed in solution by caffeine. IV. Interactions between caffeine and sulfathiazole, sulfadiazine, p-aminobenzoic acid, benzocaine, phenobarbital, and barbital.

A dihydropyridine-pyridine type redox pro-drug system was developed for delivering quaternary pyridinium salts through biological membranes. As a first application, the dihydropyridine derivative of N-methylpyridinium-2-carbaldoxime chloride (2-PAM) was synthesized using a reduction-addition-elimination sequence. The dihydro-2-PAM obtained has all the required properties for an effective transport through lipoidal barriers and it reverts easily back to 2-PAM as a result of a chemical or enzymatic oxidation process.

Improved delivery through biological membranes. 1. Synthesis and properties of 1-methyl-1,6-dihydropyridine-2-carbaldoxime, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride

Takeru Higuchi

Papers

The Physics of Tablet Compression: V. Studies on Aspirin, Lactose, Lactose-Aspirin, and Sulfadiazine Tablets

Ion pair extraction of pharmaceutical amines. Role of dipolar solvating agents in extraction of dextromethorphan.

Plastic electrodes specific for organic ions

Investigation of some complexes formed in solution by caffeine. IV. Interactions between caffeine and sulfathiazole, sulfadiazine, p-aminobenzoic acid, benzocaine, phenobarbital, and barbital.

Improved delivery through biological membranes. 1. Synthesis and properties of 1-methyl-1,6-dihydropyridine-2-carbaldoxime, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride