http://depa.fquim.unam.mx/amyd/archivero/Modeling-CrusRamirezyVargasPavonyJimenezSolorzano_11276.pdf

Modeling and comparison of dissolution profiles.

Overview of membrane science and technology membrane transport theory membrane and modules concentration polarization reverse osmosis ultrafiltration microfiltration gas separation pervaporation ion exchange membrane processes - electrodialysis carrier facilitated transport medical applications of membranes other membranes processed.

Membrane Technology and Applications

A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs

Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).

Recent advances on chitosan-based micro- and nanoparticles in drug delivery.

A study has been made of the complexing behavior of high molecular weight polyethers with a number of pharmaceutical compounds. By means of solubility procedures it has been found that although pentobarbital and barbital have little or no tendency to complex with polyethylene glycols, phenobarbital forms stable and stoichiometric molecular compounds with these macromolecular substances. Phase analysis indicates that one phenobarbital molecule is bound by two ethylene oxide units of the polyether chains. It is also shown by another phase analytical method that phenolic compounds are bound by the polyethers in the same fashion, the higher molecular weight polymers exhibiting greater complexing tendency than those of lower degrees of polymerization. Experimental data obtained on the various acids investigated indicate that these compounds are only weakly bound.

Study of possible complex formation between macromolecules and certain pharmaceuticals. III. Interaction of polyethylene glycols with several organic acids.

Direct potentiometric and titrimetric determination of methadone in urine with plastic electrodes selectiive for hydrophobic cations.

A method is presented for determining the porosity of tablet granulations in which two different density measurements are employed. They are (a) the “true” or maximum density of the granules obtained by high pressure compression of samples of the granulations, and (b) the apparent density, determined by mercury displacement. The values resulting from these two measurements on a given granulation were used to calculate the per cent void space in the granules. This report includes data from applying the experimental procedures to four test granulations, potassium bromide crystals (10-20 mesh), and glass beads. The results indicate that granulations prepared by the wet granulation method, using starch paste, had approximately 30% void space, while aspirin granulation, prepared by the slugging process, had approximately 3% void space.

The Physics of Tablet Compression XI.:Determination of Porosity of Tablet Granulations

N‐halo derivatives III: Stabilization of nitrogen‐chlorine bond in N‐chloroamino acid derivatives

N-Methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, the pro-drug of 2-PAM, was found to be converted in vivo to 2-PAM, rapidly and quantitatively. The significantly changed properties of the pro-2-PAM resulted in a longer biological half-life and a favorable distribution of 2-PAM formed upon its oxidation. No new metabolite was found when pro-2-PAM was administered intravenously; however, a new metabolic product was formed when the pro-drug was given by oral route.

Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride.

Takeru Higuchi

Papers

Study of possible complex formation between macromolecules and certain pharmaceuticals. III. Interaction of polyethylene glycols with several organic acids.

Direct potentiometric and titrimetric determination of methadone in urine with plastic electrodes selectiive for hydrophobic cations.

The Physics of Tablet Compression XI.:Determination of Porosity of Tablet Granulations

N‐halo derivatives III: Stabilization of nitrogen‐chlorine bond in N‐chloroamino acid derivatives

Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride.