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Takeru Higuchi

Researcher at University of Wisconsin-Madison

Publications -  206
Citations -  11538

Takeru Higuchi is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Aqueous solution & Solubility. The author has an hindex of 37, co-authored 206 publications receiving 11032 citations. Previous affiliations of Takeru Higuchi include Smith, Kline & French & Merck & Co..

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Journal ArticleDOI

Reversible association of caffeine and of some caffeine homologs in aqueous solution.

David Guttman, +1 more
- 01 Jan 1957 - 
TL;DR: Experimental studies involving partitioning between two solvents suggest that caffeine undergoes rather marked association in aqueous solution, existing primarily as monomer, dimer, and tetramer, while 1-ethyltheobromine appears to exist in aQueous solution only in monomeric and dimeric forms.
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Prodrugs of 6-Thiopurines: Enhanced Delivery Through the Skin

Kenneth B. Sloan, +5 more
- 01 Apr 1983 - 
TL;DR: The pivaloyloxymethyl derivatives showed the greatest potential for enhancing the penetration of the thiopurines through the skin, and VII and XI were the most effective; they delivered 5 and 13 times, respectively, more 6-mercaptopurine than 6-MERcaptopirine itself.
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Study of possible complex formation between macromolecules and certain pharmaceuticals. I. Polyvinylpyrrolidone with sulfathiazole, procaine hydrochloride, sodium salicylate, benzyl penicillin, chloramphenicol, mandelic acid, caffeine, theophylline, and cortisone.

Takeru Higuchi, +1 more
- 01 Jul 1954 - 
TL;DR: Experimental data were obtained supporting the existence of complexes in solution with some pharmaceuticals such as sulfathiazole, sodium salicylate, chloramphenicol, and mandelic acid, and no evidence of complex formation was detected between polyvinylpyrrolidone and procaine hydrochloride.
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Physics of tablet compression. XV. Thermodynamic and kinetic aspects of adhesion under pressure.

Albert S. Rankell, +1 more
- 01 Apr 1968 - 
TL;DR: A theoretical analysis has been made of the processes by which interparticle adhesion can occur during the compression of tablet granulations in the absence of added fluid adhesives, and the Clapeyron equation is modified to take into account the nonuniformity of the pressures exerted on the particles during compression.
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Study of Possible Complex Formation between Macromolecules and Certain Pharmaceuticals*: II. Polyvinylpyrrolidone with p-Aminobenzoic Acid, Aminopyrine, Benzoic Acid, Salicylic Acid, p-Hydroxybenzoic Acid, m-Hydroxybenzoic Acid, Citric Acid, and Phenobarbital

Takeru Higuchi, +1 more
- 01 Jul 1954 - 
TL;DR: The similarity of the influence of chemical structure on the stability of the PVP complexes as compared to the caffeine complexes indicates that a similar mechanism may be responsible for both series.