K
Kazuto Hoshi
Researcher at University of Tokyo
Publications - 224
Citations - 6075
Kazuto Hoshi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Cartilage & Chondrocyte. The author has an hindex of 38, co-authored 210 publications receiving 5367 citations. Previous affiliations of Kazuto Hoshi include Niigata University & Teikyo University.
Papers
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Journal ArticleDOI
Osteoarthritis development in novel experimental mouse models induced by knee joint instability.
Satoru Kamekura,Kazuto Hoshi,Takashi Shimoaka,Ung-il Chung,Hirotaka Chikuda,Takashi Yamada,M. Uchida,Naoshi Ogata,Atsushi Seichi,Kozo Nakamura,Hiroshi Kawaguchi +10 more
TL;DR: Four types of mouse models exhibiting various speeds of OA progression are established by applying a mouse genomics approach to the models, so that molecular backgrounds in various stages of Oa development can be clarified.
Journal ArticleDOI
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability
Satoru Kamekura,Yosuke Kawasaki,Kazuto Hoshi,Takashi Shimoaka,Hirotaka Chikuda,Zenjiro Maruyama,Toshihisa Komori,Shingo Sato,Shu Takeda,Gerard Karsenty,Kozo Nakamura,Ung-il Chung,Hiroshi Kawaguchi +12 more
TL;DR: RUNX-2 contributes to the pathogenesis of OA through chondrocyte hypertrophy and matrix breakdown after the induction of joint instability, as compared with wild-type mice.
Journal ArticleDOI
Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways.
Yusuke Shinoda,Masayuki Yamaguchi,Naoshi Ogata,Toru Akune,Naoto Kubota,Toshimasa Yamauchi,Yasuo Terauchi,Takashi Kadowaki,Yasuhiro Takeuchi,Seiji Fukumoto,Toshiyuki Ikeda,Kazuto Hoshi,Ung-il Chung,Kozo Nakamura,Hiroshi Kawaguchi +14 more
TL;DR: In this article, the authors investigated the regulation of bone metabolism by adiponectin, a representative adipokine, by analyzing deficient and overexpressing transgenic mice.
Journal ArticleDOI
Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling
Naohiro Kawamura,Fumitaka Kugimiya,Yasushi Oshima,Shinsuke Ohba,Toshiyuki Ikeda,Taku Saito,Yusuke Shinoda,Yosuke Kawasaki,Naoshi Ogata,Kazuto Hoshi,Toru Akiyama,William S. Chen,Nissim Hay,Kazuyuki Tobe,Takashi Kadowaki,Yoshiaki Azuma,Sakae Tanaka,Kozo Nakamura,Ung-il Chung,Hiroshi Kawaguchi +19 more
TL;DR: The molecular network found in this study will provide a basis for rational therapeutic targets for bone disorders and a novel role of Akt1/forkhead box class O (FoxO) 3a/Bim axis in the apoptosis of osteoblasts is revealed.
Journal ArticleDOI
Cartilage tissue engineering using human auricular chondrocytes embedded in different hydrogel materials
Hisayo Yamaoka,Hirotaka Asato,Toru Ogasawara,Satoru Nishizawa,Tsuguharu Takahashi,Takashi Nakatsuka,Isao Koshima,Kozo Nakamura,Hiroshi Kawaguchi,Ung-il Chung,Tsuyoshi Takato,Kazuto Hoshi +11 more
TL;DR: To seek a suitable scaffold for cartilage tissue engineering, various hydrogel materials originating from animals, plants, or synthetic peptides are compared to suggest a weakness in gelling ability and storage of cells and matrices.