Tamar Juven-Gershon

TL;DR: The findings suggest that the core promoter and basal transcription factors are important yet mostly unexplored components in the regulation of gene expression.

TL;DR: In this paper, the role of Ser20, a potential phosphorylation site in human p53, in the regulation of p53 stability and function was examined, and it was shown that substituting Ser20 by Ala (p53-Ala20) significantly increases the susceptibility of human P53 to negative regulation by Mdm2 in vivo, as measured by apoptosis and transcription activation assays.

TL;DR: The core promoter is a sophisticated gateway to transcription that determines which signals will lead to transcription initiation and may contain many different sequence motifs that specify different mechanisms of transcription and responses to enhancers.

TL;DR: It is reported that in murine cells p53 activates an internal mdm2 promoter (P2) located near the 3' end of intron 1, resulting in mRNA whose transcription starts within exon 2, effectively modulating both the amount and the nature of MDM2 polypeptides through activation of the internal P2 promoter.

TL;DR: The design and analysis of a potent core promoter, termed super core promoter 1 (SCP1), which directs high amounts of transcription by RNA polymerase II in metazoans is described, which is distinctly stronger than the cytomegalovirus IE1 and adenovirus major late (AdML) core promoters both in vitro and in vivo.