T
Tamas L. Horvath
Researcher at Yale University
Publications - 513
Citations - 48274
Tamas L. Horvath is an academic researcher from Yale University. The author has contributed to research in topics: Hypothalamus & Energy homeostasis. The author has an hindex of 107, co-authored 483 publications receiving 42023 citations. Previous affiliations of Tamas L. Horvath include Humboldt State University & University of West Hungary.
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Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis.
Alicia G. Gómez-Valadés,Macarena Pozo,Luis Varela,Mehdi Boutagouga Boudjadja,Sara Ramírez,Iñigo Chivite,Elena Eyre,Roberta Haddad-Tóvolli,Arnaud Obri,Maria Milà-Guasch,Jordi Altirriba,Marc Schneeberger,Monica Imbernon,Angela R. Garcia-Rendueles,Pau Gama-Perez,Jonathan Rojo-Ruiz,Bence Rácz,Maria Teresa Alonso,Ramon Gomis,Antonio Zorzano,Giuseppe D'Agostino,Clara V. Alvarez,Rubén Nogueiras,Pablo M. Garcia-Roves,Tamas L. Horvath,Tamas L. Horvath,Marc Claret +26 more
TL;DR: The results unveil a novel axis that connects OPA1 in POMC neurons with mitochondrial cristae, Ca2+ homeostasis, and WAT lipolysis in the regulation of energy balance.
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Discrete molecular dynamics can predict helical prestructured motifs in disordered proteins.
Dániel Szöllősi,Tamas L. Horvath,Kyou-Hoon Han,Nikolay V. Dokholyan,Peter Tompa,Lajos Kalmar,Tamás Hegedűs +6 more
TL;DR: DMD simulations combined with replica exchange (RX) method efficiently samples the conformational space and detects regions populating α-helical conformational states in disordered protein regions and provides a breakthrough in the structural and dynamical characterization of disordered proteins.
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Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival
TL;DR: In monolayer cultures of retinal cells, elevated UCP2 levels increased cell survival and rendered the cells independent of the survival-promoting effects of the neurotrophic factors BDNF and CNTF, which implicate U CP2 as an important regulator ofretinal neuron survival both during development and in adult animals.
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GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function.
Tamas L. Horvath,Derek M. Erion,John D. Elsworth,Robert H. Roth,Gerald I. Shulman,Zane B. Andrews,Zane B. Andrews +6 more
TL;DR: The results show the neuroprotective properties of GPA in a mouse model of Parkinson's disease are partially mediated by AMPK and mitochondrial function.
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Rationale, Design, and Methodological Aspects of the BUDAPEST‐GLOBAL Study (Burden of Atherosclerotic Plaques Study in Twins—Genetic Loci and the Burden of Atherosclerotic Lesions)
Pál Maurovich-Horvat,David Laszlo Tarnoki,Adam Domonkos Tarnoki,Tamas L. Horvath,Adam L. Jermendy,Márton Kolossváry,Bálint Szilveszter,Viktor Vörös,Attila Kovács,Andrea Agnes Molnar,Levente Littvay,Hildo J. Lamb,Szilard Voros,György Jermendy,Béla Merkely +14 more
TL;DR: The BUDAPEST‐GLOBAL study provides a unique framework to shed some light on the genetic and environmental influences of cardiometabolic disorders.