T
Tamas L. Horvath
Researcher at Yale University
Publications - 513
Citations - 48274
Tamas L. Horvath is an academic researcher from Yale University. The author has contributed to research in topics: Hypothalamus & Energy homeostasis. The author has an hindex of 107, co-authored 483 publications receiving 42023 citations. Previous affiliations of Tamas L. Horvath include Humboldt State University & University of West Hungary.
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Journal ArticleDOI
Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding.
TL;DR: This review will highlight both classically defined and emerging aspects of brain control of energy homeostasis, suggesting that emerging data connect circuits controlling feeding and energy balance with higher brain functions and degenerative processes.
Journal ArticleDOI
Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity
TL;DR: It is shown that mitochondria number decrease but their size increase in orexigenic agouti-related protein (Agrp) neurons during the transition from fasted to fed to overfed state, unmasking an important role for mitochondrial dynamics governed by Mfn1 and Mfn2 in Agrp neurons in central regulation of whole-body energy metabolism.
Posted ContentDOI
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Eric Song,Ce Zhang,Benjamin Israelow,Alice Lu-Culligan,Alba Vieites Prado,Sophie Skriabine,Peiwen Lu,Orr-El Weizman,Feimei Liu,Yile Dai,Klara Szigeti-Buck,Yuki Yasumoto,Guilin Wang,Christopher Castaldi,Jaime Heltke,Evelyn Ng,John Wheeler,Mia Madel Alfajaro,Etienne Levavasseur,Benjamin Fontes,Neal G. Ravindra,David van Dijk,Shrikant Mane,Murat Gunel,Aaron M. Ring,Syed A. Jaffar Kazmi,Kai Zhang,Craig B. Wilen,Tamas L. Horvath,Isabelle Plu,Stéphane Haïk,Jean-Leon Thomas,Jean-Leon Thomas,Angeliki Louvi,Shelli F. Farhadian,Anita Huttner,Danielle Seilhean,Nicolas Renier,Kaya Bilguvar,Akiko Iwasaki,Akiko Iwasaki +40 more
TL;DR: Evidence is provided for the neuroinvasive capacity of SARS-CoV2, and an unexpected consequence of direct infection of neurons by SARS -CoV-2 is demonstrated.
Journal ArticleDOI
Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson's disease and memory.
Csaba Leranth,Robert H. Roth,John D. Elsworth,Frederick Naftolin,Tamas L. Horvath,D. Eugene Redmond +5 more
TL;DR: Observations show the essential role of estrogen in maintaining the integrity of the nigral dopamine system, suggest a new treatment strategy for patients with Parkinson's disease and with certain forms of memory-impairing disorders, and provide another rationale for estrogen replacement therapy for postmenopausal women.
Journal ArticleDOI
Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
Jae Geun Kim,Shigetomo Suyama,Marco Koch,Sungho Jin,Pilar Argente-Arizón,Jesús Argente,Zhong-Wu Liu,Marcelo R. Zimmer,Jin Kwon Jeong,Klara Szigeti-Buck,Yuanqing Gao,Cristina García-Cáceres,Chun-Xia Yi,Natalina Salmaso,Flora M. Vaccarino,Julie A. Chowen,Sabrina Diano,Marcelo O. Dietrich,Matthias H. Tschöp,Tamas L. Horvath +19 more
TL;DR: Data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin in mice with astrocyte-specific leptin receptor deficiency.