T
Tanja K. Rudolph
Researcher at Ruhr University Bochum
Publications - 164
Citations - 4717
Tanja K. Rudolph is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 35, co-authored 118 publications receiving 3780 citations. Previous affiliations of Tanja K. Rudolph include University of Hamburg & University of Cologne.
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Journal ArticleDOI
Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids
Alison L. Groeger,Chiara Cipollina,Marsha P. Cole,Steven R. Woodcock,Gustavo Bonacci,Tanja K. Rudolph,Volker Rudolph,Bruce A. Freeman,Francisco J. Schopfer +8 more
TL;DR: The data support the idea that EFOX are signaling mediators that transduce the beneficial clinical effects of omega-3 fatty acids, COX-2 and aspirin, and confirm the anti-inflammatory nature of DHA- and DPA-derived EFOX.
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Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.
Volker Rudolph,René Andrié,Tanja K. Rudolph,Kai Friedrichs,Anna Klinke,Birgit Hirsch-Hoffmann,Alexander P. Schwoerer,Denise Lau,Xiaoming Fu,Karin Klingel,Karsten Sydow,Michael Didié,Michael Didié,Anika Seniuk,Eike Christin Von Leitner,Katalin Szoecs,Jan W. Schrickel,Hendrik Treede,Ulrich Wenzel,Thorsten Lewalter,Georg Nickenig,Wolfram-Hubertus Zimmermann,Wolfram-Hubertus Zimmermann,Thomas Meinertz,Rainer H. Böger,Hermann Reichenspurner,Bruce A. Freeman,Thomas Eschenhagen,Heimo Ehmke,Stanley L. Hazen,Stephan Willems,Stephan Baldus +31 more
TL;DR: Experimental and clinical evidence for the mechanistic involvement of myeloperoxidase (MPO), a heme enzyme abundantly expressed by neutrophils, in the pathophysiology of atrial fibrillation is provided.
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Transduction of Redox Signaling by Electrophile-Protein Reactions
TL;DR: Advances in mass spectrometry and affinity-chemistry strategies have improved the detection of electrophile-induced protein modifications both in vitro and in vivo and have revealed a high degree of amino acid and protein selectivity of Electrophilic PTM.
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Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.
Volker Rudolph,Volker Rudolph,Tanja K. Rudolph,Tanja K. Rudolph,Francisco J. Schopfer,Gustavo Bonacci,Steven R. Woodcock,Marsha P. Cole,Paul R. S. Baker,Ravi Ramani,Bruce A. Freeman +10 more
TL;DR: This study reveals the de novo generation of fatty acid nitration products in vivo and reveals the anti-inflammatory and potential therapeutic actions of OA-NO(2) in myocardial I/R injury.
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Heparins Increase Endothelial Nitric Oxide Bioavailability by Liberating Vessel-Immobilized Myeloperoxidase
Stephan Baldus,Volker Rudolph,Mika Roiss,Wulf D. Ito,Tanja K. Rudolph,Jason P. Eiserich,Karsten Sydow,Denise Lau,Katalin Szöcs,Anna Klinke,Lukáš Kubala,Lars Berglund,Sonja Schrepfer,Tobias Deuse,Munif Haddad,Tim Risius,Hanno U. Klemm,Hermann Reichenspurner,Thomas Meinertz,Thomas Heitzer +19 more
TL;DR: Mobilization of vessel-associated MPO may represent an important mechanism by which heparins exert antiinflammatory effects and increase vascular NO bioavailability in humans.