T
Tanja Lövgren
Researcher at Uppsala University
Publications - 31
Citations - 1968
Tanja Lövgren is an academic researcher from Uppsala University. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 14, co-authored 22 publications receiving 1702 citations. Previous affiliations of Tanja Lövgren include Uppsala University Hospital & Swedish University of Agricultural Sciences.
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Journal ArticleDOI
Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.
TL;DR: Necrotic and late apoptotic cells release material that, combined with SLE IgG, induces production of IFN alpha in PDCs, and the presence of Sle IgG was necessary, and its activity correlated with the existence of antibodies to RNA-binding proteins, but not anti-DNA antibodies.
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Activation of the type I interferon system in primary Sjogren's syndrome : a possible etiopathogenic mechanism
Ullvi Båve,Gunnel Nordmark,Tanja Lövgren,Johan Rönnelid,Stefan Cajander,Maija-Leena Eloranta,Gunnar V. Alm,Lars Rönnblom +7 more
TL;DR: Patients with primary SS have an activated type I IFN system that promotes the autoimmune process by a vicious circle-like mechanism, with increased autoantibody production and formation of more endogenous IFNalpha inducers.
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Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA.
Tanja Lövgren,Maija-Leena Eloranta,Berthold Kastner,Marie Wahren-Herlenius,Gunnar V. Alm,Lars Rönnblom +5 more
TL;DR: The finding that U1 snRNA and hY1RNA have IFNalpha-inducing capacity indicates that immune complexes containing such RNA, for example U1snRNP particles, can be at least partly responsible for the ongoing IFN alpha production seen in SLE and SS.
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A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia
Gunilla Enblad,Hannah Karlsson,Gustav Gammelgård,Jessica Wenthe,Tanja Lövgren,Rose-Marie Amini,Kristina I. Wikstrom,Magnus Essand,Barbara Savoldo,Helene Hallböök,Martin Höglund,Gianpietro Dotti,Malcolm K. Brenner,Hans Hagberg,Angelica Loskog +14 more
TL;DR: Third-generation CARs may be efficient in patients with advanced B-cell lymphoproliferative malignancy with only modest toxicity and immune profiling pre- and posttreatment can be used to find response biomarkers.
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Type I interferon system activation and association with disease manifestations in systemic sclerosis
Maija-Leena Eloranta,Karin Franck-Larsson,Tanja Lövgren,Sebastian Kalamajski,Anders Rönnblom,Kristofer Rubin,Gunnar V. Alm,Lars Rönnblom +7 more
TL;DR: An activated type I IFN system previously seen in several other systemic autoimmune diseases is also present in SSc and may contribute to the vascular pathology and affect the profibrotic process.