M
Maija-Leena Eloranta
Researcher at Swedish University of Agricultural Sciences
Publications - 24
Citations - 4067
Maija-Leena Eloranta is an academic researcher from Swedish University of Agricultural Sciences. The author has contributed to research in topics: Interferon & Immune system. The author has an hindex of 22, co-authored 24 publications receiving 3845 citations. Previous affiliations of Maija-Leena Eloranta include Uppsala University Hospital & University of Agriculture, Faisalabad.
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Journal ArticleDOI
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Snaevar Sigurdsson,Gunnel Nordmark,Harald H H Göring,Katarina Lindroos,Ann-Christin Wiman,Gunnar Sturfelt,Andreas Jönsen,Solbritt Rantapää-Dahlqvist,Bozena Möller,Juha Kere,Sari Koskenmies,Elisabeth Widen,Maija-Leena Eloranta,Heikki Julkunen,Helga Kristjansdottir,Kristjan Steinsson,Gunnar V. Alm,Lars Rönnblom,Ann-Christine Syvänen +18 more
TL;DR: The results support a disease mechanism in SLE that involves key components of the type I IFN system, and identify SNPs that displayed strong signals in joint analysis of linkage and association with SLE.
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Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.
TL;DR: Necrotic and late apoptotic cells release material that, combined with SLE IgG, induces production of IFN alpha in PDCs, and the presence of Sle IgG was necessary, and its activity correlated with the existence of antibodies to RNA-binding proteins, but not anti-DNA antibodies.
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Activation of the type I interferon system in primary Sjogren's syndrome : a possible etiopathogenic mechanism
Ullvi Båve,Gunnel Nordmark,Tanja Lövgren,Johan Rönnelid,Stefan Cajander,Maija-Leena Eloranta,Gunnar V. Alm,Lars Rönnblom +7 more
TL;DR: Patients with primary SS have an activated type I IFN system that promotes the autoimmune process by a vicious circle-like mechanism, with increased autoantibody production and formation of more endogenous IFNalpha inducers.
Journal ArticleDOI
Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG.
TL;DR: It is concluded that FcγRIIa on NIPC/PDC is involved in the activation of IFN-α production by interferogenic immune complexes, but may also mediate inhibitory signals.