G
Gunnel Nordmark
Researcher at Uppsala University
Publications - 106
Citations - 6434
Gunnel Nordmark is an academic researcher from Uppsala University. The author has contributed to research in topics: Single-nucleotide polymorphism & Autoantibody. The author has an hindex of 34, co-authored 94 publications receiving 5479 citations. Previous affiliations of Gunnel Nordmark include Science for Life Laboratory & Uppsala University Hospital.
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Journal ArticleDOI
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
Vesela Gateva,Johanna K. Sandling,Geoff Hom,Kimberly E. Taylor,Sharon A. Chung,Xin Sun,Ward Ortmann,Roman Kosoy,Ricardo C. Ferreira,Gunnel Nordmark,Iva Gunnarsson,Elisabet Svenungsson,Leonid Padyukov,Gunnar Sturfelt,Andreas Jönsen,Anders A. Bengtsson,Solbritt Rantapää-Dahlqvist,Emily C. Baechler,Elizabeth E. Brown,Graciela S. Alarcón,Jeffrey C. Edberg,Rosalind Ramsey-Goldman,Gerald McGwin,John D. Reveille,Luis M. Vilá,Robert P. Kimberly,Susan Manzi,Michelle Petri,Annette Lee,Peter K. Gregersen,Michael F. Seldin,Lars Rönnblom,Lindsey A. Criswell,Ann-Christine Syvänen,Timothy W. Behrens,Robert R. Graham +35 more
TL;DR: The results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.
Journal ArticleDOI
Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Snaevar Sigurdsson,Gunnel Nordmark,Harald H H Göring,Katarina Lindroos,Ann-Christin Wiman,Gunnar Sturfelt,Andreas Jönsen,Solbritt Rantapää-Dahlqvist,Bozena Möller,Juha Kere,Sari Koskenmies,Elisabeth Widen,Maija-Leena Eloranta,Heikki Julkunen,Helga Kristjansdottir,Kristjan Steinsson,Gunnar V. Alm,Lars Rönnblom,Ann-Christine Syvänen +18 more
TL;DR: The results support a disease mechanism in SLE that involves key components of the type I IFN system, and identify SNPs that displayed strong signals in joint analysis of linkage and association with SLE.
Journal ArticleDOI
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
Robert R. Graham,Chieko Kyogoku,Snaevar Sigurdsson,Irina A. Vlasova,Leela Davies,Leela Davies,Emily C. Baechler,Robert M. Plenge,Robert M. Plenge,Thearith Koeuth,Ward A. Ortmann,Ward A. Ortmann,Geoffrey Hom,Geoffrey Hom,Jason W. Bauer,Clarence Gillett,Noël P. Burtt,Noël P. Burtt,Deborah S. Cunninghame Graham,Robert C. Onofrio,Robert C. Onofrio,Michelle Petri,Iva Gunnarsson,Elisabet Svenungsson,Lars Rönnblom,Gunnel Nordmark,Peter K. Gregersen,Kathy L. Moser,Patrick M. Gaffney,Lindsey A. Criswell,Timothy J. Vyse,Ann-Christine Syvänen,Paul R. Bohjanen,Mark J. Daly,Mark J. Daly,Timothy W. Behrens,Timothy W. Behrens,David Altshuler,David Altshuler +38 more
TL;DR: Evidence is found for three functional alleles of IRF5: the previously described exon 1B splice site variant, a 30-bp in-frame insertion/deletion variant of exon 6 that alters a proline-, glutamic acid-, serine- and threonine-rich domain region, and a variant in a conserved polyA+ signal sequence that alters the length of the 3′ UTR and stability of IRf5 mRNAs.
Journal ArticleDOI
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome.
Christopher J. Lessard,Christopher J. Lessard,He Li,He Li,Indra Adrianto,John A. Ice,Astrid Rasmussen,Kiely Grundahl,Jennifer A. Kelly,Mikhail G. Dozmorov,Corinne Miceli-Richard,Simon J. Bowman,Susan C. Lester,Per Eriksson,Maija-Leena Eloranta,Johan G. Brun,Lasse G. Gøransson,Erna Harboe,Joel M. Guthridge,Kenneth M. Kaufman,Kenneth M. Kaufman,Marika Kvarnström,Helmi Jazebi,Helmi Jazebi,Deborah S. Cunninghame Graham,Martha E. Grandits,Abu N. M. Nazmul-Hossain,Ketan Patel,Adam Adler,Jacen S. Maier-Moore,Jacen S. Maier-Moore,A. Darise Farris,Michael T. Brennan,James A. Lessard,James Chodosh,Rajaram Gopalakrishnan,Kimberly S. Hefner,Glen D Houston,Andrew J.W. Huang,Pamela J. Hughes,David M Lewis,Lida Radfar,Michael D. Rohrer,Donald U. Stone,Jonathan D. Wren,Timothy J. Vyse,Patrick M. Gaffney,Judith A. James,Judith A. James,Roald Omdal,Marie Wahren-Herlenius,Gabor G. Illei,Torsten Witte,Roland Jonsson,Maureen Rischmueller,Lars Rönnblom,Gunnel Nordmark,Wan-Fai Ng,Xavier Mariette,Juan-Manuel Anaya,Nelson L. Rhodus,Barbara M. Segal,R. Hal Scofield,Courtney G. Montgomery,John B. Harley,John B. Harley,Kathy L. Sivils,Kathy L. Sivils +67 more
TL;DR: The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
Journal ArticleDOI
Activation of the type I interferon system in primary Sjogren's syndrome : a possible etiopathogenic mechanism
Ullvi Båve,Gunnel Nordmark,Tanja Lövgren,Johan Rönnelid,Stefan Cajander,Maija-Leena Eloranta,Gunnar V. Alm,Lars Rönnblom +7 more
TL;DR: Patients with primary SS have an activated type I IFN system that promotes the autoimmune process by a vicious circle-like mechanism, with increased autoantibody production and formation of more endogenous IFNalpha inducers.