T
Tapas K. Kundu
Researcher at Jawaharlal Nehru Centre for Advanced Scientific Research
Publications - 222
Citations - 9622
Tapas K. Kundu is an academic researcher from Jawaharlal Nehru Centre for Advanced Scientific Research. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 50, co-authored 206 publications receiving 8671 citations. Previous affiliations of Tapas K. Kundu include University of Rochester & Central Drug Research Institute.
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Journal ArticleDOI
Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription.
Karanam Balasubramanyam,Radhika A. Varier,Mohammed Altaf,V. Swaminathan,Nagadenahalli B. Siddappa,Udaykumar Ranga,Tapas K. Kundu +6 more
TL;DR: It is reported that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding protein (CBP) HAT activity but not of p300-associated factor, in vitro and in vivo.
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Polyisoprenylated Benzophenone, Garcinol, a Natural Histone Acetyltransferase Inhibitor, Represses Chromatin Transcription and Alters Global Gene Expression
Karanam Balasubramanyam,Mohammed Altaf,Radhika A. Varier,V. Swaminathan,Aarti Ravindran,Parag P. Sadhale,Tapas K. Kundu +6 more
TL;DR: Garinol, a polyisoprenylated benzophenone derivative from Garcinia indica fruit rind, is a potent inhibitor of histone acetyltransferases p300 and PCAF both in vitro and in vivo and alters (predominantly down-regulates) the global gene expression in HeLa cells.
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Small molecule modulators of histone acetyltransferase p300.
TL;DR: It is reported that anacardic acid from cashew nut shell liquid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferase activities and an amide derivative N-(4-chloro-3-trifluoromethyl-phenyl)-2-ethoxy-6-pentadecyl-benzamide (CTPB) is described, which remarkably activates p300 HAT activity but not that of p
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HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.
Ontario D. Lau,Ontario D. Lau,Tapas K. Kundu,Raymond E. Soccio,Slimane Ait-Si-Ali,Ehab M. Khalil,Alex Vassilev,Alan P. Wolffe,Yoshihiro Nakatani,Robert G. Roeder,Philip A. Cole,Philip A. Cole +11 more
TL;DR: In this paper, the authors describe the design, synthesis, and application of peptide CoA conjugates as selective HAT inhibitors for the transcriptional coactivators p300 and PCAF.
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Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo
Ernest Martinez,Vikas B. Palhan,Agneta Tjernberg,Elena S. Lymar,Armin M. Gamper,Tapas K. Kundu,Brian T. Chait,Robert G. Roeder +7 more
TL;DR: The results suggest cellular roles of STAGA in chromatin modification, transcription, and transcription-coupled processes through direct physical interactions with sequence-specific transcription activators and with components of the splicing and DNA repair machineries.