T
Tarek A.M. Almabrouk
Researcher at University of Glasgow
Publications - 7
Citations - 330
Tarek A.M. Almabrouk is an academic researcher from University of Glasgow. The author has contributed to research in topics: AMPK & Adiponectin secretion. The author has an hindex of 6, co-authored 7 publications receiving 245 citations. Previous affiliations of Tarek A.M. Almabrouk include Al Zawiya University.
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Journal ArticleDOI
Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms.
Sarah J. Mancini,Daria Boyd,Omar J. Katwan,Omar J. Katwan,Anastasiya Strembitska,Tarek A.M. Almabrouk,Tarek A.M. Almabrouk,Simon Kennedy,Timothy M. Palmer,Ian P. Salt +9 more
TL;DR: It is indicated that clinically-relevant canagliflozin concentrations directly inhibit endothelial pro-inflammatory chemokine/cytokine secretion by AMPK-dependent and -independent mechanisms without affecting early IL-1β signalling.
Journal ArticleDOI
Perivascular fat, AMP-activated protein kinase and vascular diseases
TL;DR: A current perspective on how PVAT may influence vascular function via AMPK is provided and how modulating AMPK activity using pharmacological agents could be exploited therapeutically to treat cardiometabolic diseases is attempted.
Journal ArticleDOI
High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion.
Tarek A.M. Almabrouk,Tarek A.M. Almabrouk,Anna White,Azizah Ugusman,Azizah Ugusman,Dominik Skiba,Dominik Skiba,Omar J. Katwan,Omar J. Katwan,Husam S.F. Alganga,Husam S.F. Alganga,Tomasz J. Guzik,Tomasz J. Guzik,Rhian M. Touyz,Ian P. Salt,Simon Kennedy +15 more
TL;DR: High-fat diet causes an inflammatory infiltrate, reduced AMPK phosphorylation and attenuates the anticontractile effect of murine aortic PVAT, suggesting that AMPK may protect the vessel against deleterious changes in response to HFD.
Journal ArticleDOI
Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release
Tarek A.M. Almabrouk,Tarek A.M. Almabrouk,Azizah Ugusman,Omar J. Katwan,Omar J. Katwan,Ian P. Salt,Simon Kennedy +6 more
TL;DR: The role of AMPK within PVAT in mediating the anticontractile effect of PVAT is investigated and it is found that it may mediate the vascular effects of adiponectin.
Journal ArticleDOI
AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis.
Omar J. Katwan,Omar J. Katwan,Fatmah Alghamdi,Fatmah Alghamdi,Tarek A.M. Almabrouk,Tarek A.M. Almabrouk,Sarah J. Mancini,Simon Kennedy,Jonathan S. Oakhill,Jonathan S. Oakhill,John W. Scott,John W. Scott,John W. Scott,Ian P. Salt +13 more
TL;DR: Data indicate that increased expression of AMPKβ2 is an important feature of efficient adipogenesis, and small molecules that selectively influence AMPK heterotrimers containing specific AM PKβ subunit isoforms have been developed, including MT47-100, which selectively inhibits complexes containing AMPK β2.