Tariq R. Altamimi

TL;DR: A novel beneficial effect of Ang 1–7 on diabetic cardiomyopathy that involved a reduction in cardiac hypertrophy and lipotoxicity, adipose inflammation, and an upregulation of adipose triglyceride lipase is identified.

TL;DR: Nrg4 exerts pleiotropic beneficial effects on energy balance and glucose and lipid metabolism to ameliorate obesity-associated metabolic disorders and may improve both type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) in patients.

TL;DR: It is concluded that impaired cardiac BCAA catabolism and insulin signaling occur in human heart failure, while enhancing BCAA oxidation can improve cardiac function in the failing mouse heart.

TL;DR: These data are the first suggesting that acetylation and succinylation of the key metabolic enzymes in newborn hearts play a crucial role in cardiac energy metabolism with maturation.

TL;DR: Not only can ketones become the major fuel of the heart with no inhibitory effect on cardiac glucose oxidation, but they can provide the healthy heart with an excess energy supply, with no changes to cardiac function, resulting in a mismatch between reducing equivalents supply and cardiac ATP production, ultimately contributing to a decrease in cardiac efficiency.