J
John R. Ussher
Researcher at University of Alberta
Publications - 15
Citations - 441
John R. Ussher is an academic researcher from University of Alberta. The author has contributed to research in topics: Insulin resistance & Pyruvate dehydrogenase complex. The author has an hindex of 7, co-authored 15 publications receiving 256 citations.
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Journal ArticleDOI
Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.
Kim L. Ho,Liyan Zhang,Cory S. Wagg,Rami Al Batran,Keshav Gopal,Jody Levasseur,Teresa C. Leone,Jason R.B. Dyck,John R. Ussher,Deborah M. Muoio,Daniel P. Kelly,Gary D. Lopaschuk +11 more
TL;DR: Increasing ketone oxidation rates in failing hearts increases overall energy production without compromising glucose or fatty acid metabolism, albeit without increasing cardiac efficiency.
Journal ArticleDOI
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
Golam M. Uddin,Liyan Zhang,Saumya Shah,Arata Fukushima,Cory S. Wagg,Keshav Gopal,Rami Al Batran,Simran Pherwani,Kim L. Ho,Jamie Boisvenue,Qutuba G. Karwi,Qutuba G. Karwi,Tariq R. Altamimi,David S. Wishart,Jason R.B. Dyck,John R. Ussher,Gavin Y. Oudit,Gary D. Lopaschuk +17 more
TL;DR: It is concluded that impaired cardiac BCAA catabolism and insulin signaling occur in human heart failure, while enhancing BCAA oxidation can improve cardiac function in the failing mouse heart.
Journal ArticleDOI
Targeting ceramide metabolism in obesity.
TL;DR: Because a reduction in skeletal muscle ceramide levels is frequently associated with improvements in insulin sensitivity in humans, the beneficial findings reported for reducing ceramides in preclinical studies may have clinical application in humans.
Journal ArticleDOI
FoxO1 Regulates Myocardial Glucose Oxidation Rates via Transcriptional Control of Pyruvate Dehydrogenase Kinase 4 Expression
Keshav Gopal,Bruno Saleme,Rami Al Batran,Hanin Aburasayn,Amina Eshreif,Kim L. Ho,Wayne K. Ma,Malak Almutairi,Farah Eaton,Manoj Gandhi,Edwards A. Park,Edwards A. Park,Gopinath Sutendra,John R. Ussher +13 more
TL;DR: It is demonstrated that pyruvate dehydrogenase kinase 4 is a direct transcriptional target of FoxO1 (but not FoxO3/FoxO4) in the heart, thereby controlling PDH activity and subsequent glucose oxidation rates.
Journal ArticleDOI
Cardiac-Specific Deletion of Pyruvate Dehydrogenase Impairs Glucose Oxidation Rates and Induces Diastolic Dysfunction.
TL;DR: It does appear that forced restriction of glucose oxidation in the hearts of Pdha1Cardiac−/− mice is sufficient to produce a cardiomyopathy-like phenotype, independent of the perturbed metabolic milieu observed in obesity and/or T2D.