Tarson Tolentino-Cortez

TL;DR: It is demonstrated that transgenically preventing n-3 PUFA deficiency selectively in D2-expressing neurons normalizes MSN collateral inhibition and enhances motivation, and suggests that lower n- 3 PUFA biostatus in psychopathologies could participate in the etiology of reward-related symptoms.

TL;DR: In this article, the effects of tetraspanin CD9 gene deletion were compared with those elicited by cytopermeable peptides with blocking properties against TRS-CD9, showing that CD9 peptide induced an increase in lysosome numbers, while CD9 deletion augmented the number of MVB and EV secretion.

TL;DR: A new methodology is presented that combines micro-arrays with mass spectrometry to obtain the lipid fingerprint of samples of different nature in a standardized and fast way, with minimal sample consumption.

TL;DR: A novel technology that enables the simultaneous determination of tissue specific AChE activity, as well as the analysis and screening of specific inhibitors, by using cell membrane microarrays is reported, demonstrating the major potential of this microarray’s technology.

TL;DR: It is suggested that n-3 PUFAs act as allosteric modulators of the D2R and provide a putative mechanism for their potentiating effect on antipsychotic efficacy.