Gabriel Barreda-Gómez

TL;DR: It is shown that acute cannabinoid-induced memory impairment in mice requires activation of hippocampal mtCB1 receptors, and this data reveal that bioenergetic processes are primary acute regulators of cognitive functions.

TL;DR: It is demonstrated that the performance of MBT is superior to that of the matrixes commonly employed for lipids, due to its low vapor pressure, its low acidity, and the formation of small crystals, although because of the strong background at low m/z, it precludes detection of species below approximately 500 Da.

TL;DR: The present study shows the lipid distribution obtained by MALDI-TOF IMS in human frontal cortex, hippocampus, and striatal area, together with functional autoradiography of cannabinoid and LPA receptors in postmortem human brain samples.

TL;DR: Comparison between the spectra from lipid extracts devoid of proteins and those recorded directly from the tissue unambiguously show that the differences in lipid composition between gray and white matter observed in the mass images are not an artifact due to microenvironmental influences of each anatomical area on the signal intensity, but real variations in the lipid composition.

TL;DR: It is demonstrated that transgenically preventing n-3 PUFA deficiency selectively in D2-expressing neurons normalizes MSN collateral inhibition and enhances motivation, and suggests that lower n- 3 PUFA biostatus in psychopathologies could participate in the etiology of reward-related symptoms.