T
Tatsuya Kawaguchi
Researcher at Kumamoto University
Publications - 100
Citations - 1880
Tatsuya Kawaguchi is an academic researcher from Kumamoto University. The author has contributed to research in topics: Paroxysmal nocturnal hemoglobinuria & Nilotinib. The author has an hindex of 23, co-authored 95 publications receiving 1726 citations. Previous affiliations of Tatsuya Kawaguchi include Wakayama Medical University & Kumamoto Health Science University.
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Journal ArticleDOI
Discontinuation of imatinib in Japanese patients with chronic myeloid leukemia
Naoto Takahashi,Taiichi Kyo,Yasuhiro Maeda,Takashi Sugihara,Kensuke Usuki,Tatsuya Kawaguchi,Noriko Usui,Shinichiro Okamoto,Yokiko Ohe,Shigeki Ohtake,Kunio Kitamura,Masahide Yamamoto,Hirofumi Teshima,Toshiko Motoji,Toshiharu Tamaki,Kenichi Sawada,Kazuma Ohyashiki +16 more
TL;DR: The depth of the molecular response should be a factor influencing long-term sustained complete molecular response after discontinuation of imatinib and an immunological mechanism modified by interferon-α might control chronic myeloid leukemia stem cells.
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Apoptosis resistance of blood cells from patients with paroxysmal nocturnal hemoglobinuria, aplastic anemia, and myelodysplastic syndrome
Kentaro Horikawa,Hideki Nakakuma,Tatsuya Kawaguchi,Norihiro Iwamoto,Shoichi Nagakura,Tadashi Kagimoto,Kiyoshi Takatsuki +6 more
TL;DR: Granulocytes obtained from 11 patients with PNH were apparently less susceptible than those from 20 healthy individuals to both spontaneous apoptosis without any ligands and that induced by anti-FAS antibody in vitro, which supports the pathogenic implication of apoptosis in marrow injury of PNH and related stem cell disorders.
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Immunoselection by natural killer cells of PIGA mutant cells missing stress-inducible ULBP.
Nobuyoshi Hanaoka,Tatsuya Kawaguchi,Tatsuya Kawaguchi,Kentaro Horikawa,Kentaro Horikawa,Shoichi Nagakura,Shoichi Nagakura,Hiroaki Mitsuya,Hiroaki Mitsuya,Hideki Nakakuma +9 more
TL;DR: It is shown that leukemic K562 cells preferentially survived natural killer (NK) cell-mediated cytotoxicity in vitro when they acquired PIGA mutations, which is ascribable to the deficiency of stress-inducible GPI-linked membrane proteins ULBP1 and ULBP2, which activate NK and T cells.
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Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid Leukemia
Yukako Yamakawa,Akinobu Hamada,T Shuto,Misato Yuki,Takashi Uchida,Hirofumi Kai,Tatsuya Kawaguchi,Hideyuki Saito +7 more
TL;DR: It is suggested that imatinib is transported into cells by OATP1A2, and that SLCO 1A2 polymorphisms significantly affect imatinIB pharmacokinetics.
Journal ArticleDOI
Paroxysmal nocturnal hemoglobinuria clone in bone marrow of patients with pancytopenia
Hideki Nakakuma,Shoichi Nagakura,Norihiro Iwamoto,Tatsuya Kawaguchi,Michihiro Hidaka,Kentaro Horikawa,Tadashi Kagimoto,Tadahiro Shido,Kiyoshi Takatsuki +8 more
TL;DR: Findings indicate that detection of the PNH clone in the bone marrow of patients with aplastic anemia could be predictive of the development of PNH in patients with AA and pancytopenia.