T
Tatsuya Tamura
Researcher at Chugai Pharmaceutical Co.
Publications - 65
Citations - 3446
Tatsuya Tamura is an academic researcher from Chugai Pharmaceutical Co.. The author has contributed to research in topics: Osteoclast & Molding (process). The author has an hindex of 19, co-authored 65 publications receiving 3287 citations. Previous affiliations of Tatsuya Tamura include Massachusetts Institute of Technology & Showa University.
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Journal ArticleDOI
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.
Tatsuya Tamura,Nobuyuki Udagawa,Naoyuki Takahashi,Chisato Miyaura,Sakae Tanaka,Y Yamada,Yasuo Koishihara,Yoshiyuki Ohsugi,K Kumaki,Tetsuya Taga +9 more
TL;DR: It is suggested that increased circulating or locally produced sIL-6R induces osteoclast formation in the presence of IL-6 mediated by a mechanism involving gp130, which may play an important physiological or pathological role in conditions associated with increased osteoclastic bone resorption.
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Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors.
Sakae Tanaka,Naoyuki Takahashi,Nobuyuki Udagawa,Tatsuya Tamura,Takuhiko Akatsu,E R Stanley,Takahide Kurokawa,Tatsuo Suda +7 more
TL;DR: Results clearly indicate that M-CSF is indispensable for both proliferation of osteoclast progenitors and their differentiation into mature osteoclasts.
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Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria : Association of MMP induction with bone resorption
Kenichiro Kusano,Chisato Miyaura,Masaki Inada,Tatsuya Tamura,Akira Ito,Hideaki Nagase,Kyuichi Kamoi,Tatsuo Suda +7 more
TL;DR: The potency of induction of MMPs by IL-1 and IL-6 is closely linked to the respective bone-resorbing activity, suggesting that MMP-dependent degradation of bone matrix plays a key role in bone resorption induced by these cytokines.
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Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.
Nobuyuki Udagawa,Naoyuki Takahashi,Takenobu Katagiri,Tatsuya Tamura,S Wada,David M. Findlay,T J Martin,H Hirota,T Taga,Tadamitsu Kishimoto,Tatsuo Suda +10 more
TL;DR: The results clearly indicate that the ability of IL- 6 to induce osteoclast differentiation depends on signal transduction mediated by IL-6R expressed on osteoblastic cells but not on osteOClast progenitors.
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Endogenous bone-resorbing factors in estrogen deficiency: Cooperative effects of IL-1 and IL-6
Chisato Miyaura,Kenichiro Kusano,Toshihide Masuzawa,Osamu Chaki,Yoshiko Onoe,Maki Aoyagi,Takahisa Sasaki,Tatsuya Tamura,Yasuo Koishihara,Yoshiyuki Ohsugi,Tatsuo Suda +10 more
TL;DR: The results suggest that the enhanced bone resorption that occurs during estrogen deficiency is due to multi‐factors rather than to a single factor.