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Nobuyuki Udagawa
Researcher at Matsumoto Dental University
Publications - 226
Citations - 27951
Nobuyuki Udagawa is an academic researcher from Matsumoto Dental University. The author has contributed to research in topics: Osteoclast & Bone resorption. The author has an hindex of 69, co-authored 216 publications receiving 26155 citations. Previous affiliations of Nobuyuki Udagawa include Showa University & St. Vincent's Institute of Medical Research.
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Journal ArticleDOI
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Kyoji Yamaguchi,Masahiko Kinosaki,Shin Ichi Mochizuki,Akihiro Tomoyasu,Kazuki Yano,Masaaki Goto,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Nobuyuki Udagawa,Naoyuki Takahashi,Tatsuo Suda +15 more
TL;DR: In this article, a membrane-bound osteoclast differentiation factor (ODF) was found to induce OCL formation from osteoblasts/stromal cells in the presence of bone-resorbing factors.
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Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.
TL;DR: Osteoblasts/stromal cells can now be replaced with RANKL and M-CSF in dealing with the whole life of osteoclasts, and new ways to treat several metabolic bone diseases caused by abnormal osteoclast recruitment and functions will be established.
Journal ArticleDOI
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
Shigeru Kotake,Nobuyuki Udagawa,Naoyuki Takahashi,Kenichiro Matsuzaki,Kanami Itoh,Shigeru Ishiyama,Seiji Saito,Kazuhiko Inoue,Naoyuki Kamatani,Matthew T. Gillespie,T. John Martin,Tatsuo Suda +11 more
TL;DR: It is suggested that IL-17 first acts on osteoblasts, which stimulates both COX-2-dependent PGE2 synthesis and ODF gene expression, which in turn induce differentiation of osteoclast progenitors into mature osteoclasts, and that IL -17 is a crucial cytokine for osteoclastic bone resorption in RA patients.
Journal ArticleDOI
Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction
Kanichiro Kobayashi,Naoyuki Takahashi,Eijiro Jimi,Nobuyuki Udagawa,Masamichi Takami,Shigeru Kotake,Nobuaki Nakagawa,Masahiko Kinosaki,Kyoji Yamaguchi,Nobuyuki Shima,Hisataka Yasuda,Tomonori Morinaga,Kanji Higashio,T. John Martin,Tatsuo Suda +14 more
TL;DR: It is demonstrated that TNF-α stimulates osteoclast differentiation in the presence of M-CSF through a mechanism independent of the ODF/RANKL–RANK system.
Journal ArticleDOI
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.
Nobuyuki Udagawa,Naoyuki Takahashi,Takuhiko Akatsu,Hirofumi Tanaka,Takahisa Sasaki,T Nishihara,T Koga,T J Martin,Tatsuo Suda +8 more
TL;DR: The results indicate that osteoclasts are also derived from the mature monocytes and macrophages when a suitable microenvironment is provided by bone marrow-derived stromal cells.