T
Tatu A. Miettinen
Researcher at Helsinki University Central Hospital
Publications - 15
Citations - 2028
Tatu A. Miettinen is an academic researcher from Helsinki University Central Hospital. The author has contributed to research in topics: Cholesterol & Ileum. The author has an hindex of 8, co-authored 15 publications receiving 1923 citations.
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Journal ArticleDOI
Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels
Martijn B. Katan,Scott M. Grundy,Peter B. Jones,Malcolm Law,Tatu A. Miettinen,Rodolfo Paoletti +5 more
TL;DR: Present evidence is sufficient to promote use of sterols and stanols for lowering LDL cholesterol levels in persons at increased risk for coronary heart disease.
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Plant sterols: biosynthesis, biological function and their importance to human nutrition.
TL;DR: Since the morbidity and mortality from cardiovascular disease have been dramatically reduced using cholesterol-lowering drugs (statins), the interest in plant sterols lies in their potential to act as a natural preventive dietary product.
Journal ArticleDOI
Dyslipidemia and a reversible decrease in insulin sensitivity induced by therapy with 13‐cis‐retinoic acid
Heikki A. Koistinen,Anita Remitz,Helena Gylling,Tatu A. Miettinen,Veikko A. Koivisto,P. Ebeling +5 more
TL;DR: This work investigated whether 13‐cis‐retinoic acid treatment decreases insulin sensitivity by studying the effects of treatment with Roaccutan on insulin sensitivity.
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Fine mapping of a gene responsible for regulating dietary cholesterol absorption; founder effects underlie cases of phytosterolaemia in multiple communities.
Mi Hye Lee,Derek Gordon,Jurg Ott,Kangmo Lu,Leiv Ose,Tatu A. Miettinen,Helena Gylling,Anton F. H. Stalenhoef,Arti Pandya,Hideki Hidaka,Bryan Brewer,Hideto Kojima,Nagahiko Sakuma,R.J. Pegoraro,Gerald Salen,Shailendra B. Patel +15 more
TL;DR: Using both homozygosity mapping, as well as informative recombination events, the sitosterolaemia gene is located at a region defined by markers D2S2294 and Afm210xe9, a distance of less than 2 cM, strongly supporting the existence of a founder effect among various populations.
Journal ArticleDOI
Adaptation of cholesterol absorption after proximal resection of porcine small intestine.
Mikko P. Pakarinen,Tatu A. Miettinen,Jouni Lauronen,Pekka Kuusanmäki,Peter Raivio,Kivistö T,Jorma Halttunen +6 more
TL;DR: After massive proximal small bowel resection, adaptation of intestinal cholesterol absorption efficiency occurs in the distal ileum closely parlleling villus hypertrophy.