T
Teresa A. Colvin
Researcher at Boston University
Publications - 4
Citations - 274
Teresa A. Colvin is an academic researcher from Boston University. The author has contributed to research in topics: Cancer cell & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 4, co-authored 4 publications receiving 221 citations.
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Journal ArticleDOI
Hsp70-Bag3 interactions regulate cancer-related signaling networks
Teresa A. Colvin,Vladimir L. Gabai,Jianlin Gong,Stuart K. Calderwood,Hu Li,Suryaram Gummuluru,Matchuk On,Smirnova Sg,Orlova Nv,Irina A. Zamulaeva,Mikel Garcia-Marcos,Xiaokai Li,Zapporah T. Young,Jennifer N. Rauch,Jason E. Gestwicki,Shinichi Takayama,Michael Y. Sherman +16 more
TL;DR: It is established that the Hsp70-Bag3 module is a broad-acting regulator of cancer cell signaling by modulating the activity of the transcription factors NF-κB, FoxM1, Hif1α, the translation regulator HuR, and the cell-cycle regulators p21 and survivin.
Journal ArticleDOI
Validation of the Hsp70–Bag3 Protein–Protein Interaction as a Potential Therapeutic Target in Cancer
Xiaokai Li,Teresa A. Colvin,Jennifer N. Rauch,Diego Acosta-Alvear,Martin Kampmann,Bryan M. Dunyak,Byron Hann,Blake T. Aftab,Megan Murnane,Min Cho,Peter Walter,Jonathan S. Weissman,Michael Y. Sherman,Jason E. Gestwicki +13 more
TL;DR: JG-98, an allosteric inhibitor of this PPI, indeed has antiproliferative activity across cancer cell lines from multiple origins and suggested that the Hsp70–Bag3 interaction may be a promising, new target for anticancer therapy.
Journal ArticleDOI
Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells.
Vladimir L. Gabai,Julia A. Yaglom,Yongmei Wang,Le Meng,Hao Shao,Geunwon Kim,Teresa A. Colvin,Jason E. Gestwicki,Michael Y. Sherman +8 more
TL;DR: The results illustrate how Hsp70 inhibitors mediate the anticancer effects by targeting both tumor cells and tumor stromal cells, with implications for the broad use of these inhibitors as tools to ablate tumor-associated macrophages that enable malignant progression.
Journal ArticleDOI
Proteotoxicity is not the reason for the dependence of cancer cells on the major chaperone Hsp70.
TL;DR: Here, using the major chaperone Hsp70 as example, it is demonstrated that its depletion does not trigger proteotoxic stress, thus refuting the model and defining the requirements for chaperones in cancer cells, which is critical for rational targeting Hsp 70 in cancer treatment.