T
Teresa Morales-Ruiz
Researcher at University of Córdoba (Spain)
Publications - 15
Citations - 1499
Teresa Morales-Ruiz is an academic researcher from University of Córdoba (Spain). The author has contributed to research in topics: DNA glycosylase & DNA methylation. The author has an hindex of 8, co-authored 12 publications receiving 1295 citations. Previous affiliations of Teresa Morales-Ruiz include National Institute of Standards and Technology & Sofia University.
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Journal ArticleDOI
ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase
Zhizhong Gong,Teresa Morales-Ruiz,Rafael R. Ariza,Teresa Roldán-Arjona,Lisa K. David,Jian-Kang Zhu +5 more
TL;DR: It is suggested that ROS1 is a DNA repair protein that represses homology-dependent transcriptional gene silencing by demethylating the target promoter DNA.
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DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases
Teresa Morales-Ruiz,Ana Pilar Ortega-Galisteo,María Isabel Ponferrada-Marín,María Isabel Martínez-Macías,Rafael R. Ariza,Teresa Roldán-Arjona +5 more
TL;DR: It is shown that DME and ROS1 catalyze the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism, providing strong biochemical evidence for the existence of an active DNA demethylation pathway in plants.
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Arabidopsis DEMETER-LIKE proteins DML2 and DML3 are required for appropriate distribution of DNA methylation marks
TL;DR: The results suggest that DML2 and DML3 are required not only for removing DNA methylation marks from improperly-methylated cytosines, but also for maintenance of high methylation levels in properly targeted sites.
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A DNA 3′ Phosphatase Functions in Active DNA Demethylation in Arabidopsis
María Isabel Martínez-Macías,Weiqiang Qian,Daisuke Miki,Olga Pontes,Yunhua Liu,Kai Tang,Renyi Liu,Teresa Morales-Ruiz,Rafael R. Ariza,Teresa Roldán-Arjona,Jian-Kang Zhu,Jian-Kang Zhu +11 more
TL;DR: This work shows that the DNA phosphatase ZDP functions downstream of ROS1 in one branch of the active DNA demethylation pathway, allowing subsequent DNA polymerization and ligation steps needed to complete the repair reactions.
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Single-nucleotide and long-patch base excision repair of DNA damage in plants
TL;DR: In this article, the authors used Arabidopsis cell extracts to monitor the repair of DNA base damage in vitro, and showed that AP sites generated after uracil excision are processed both by AP endonucleases and AP lyases, generating either 5'- or 3'-blocked ends, respectively.