T
Terje Høyvarde Clausen
Researcher at University of Tromsø
Publications - 4
Citations - 8169
Terje Høyvarde Clausen is an academic researcher from University of Tromsø. The author has contributed to research in topics: Sequestosome-1 Protein & Autophagy database. The author has an hindex of 4, co-authored 4 publications receiving 7588 citations.
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Journal ArticleDOI
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy
Serhiy Pankiv,Terje Høyvarde Clausen,Trond Lamark,Andreas Brech,Jack-Ansgar Bruun,Heidi Outzen,Aud Øvervatn,Geir Bjørkøy,Terje Johansen +8 more
TL;DR: It is demonstrated that the previously reported aggresome-like induced structures containing ubiquitinated proteins in cytosolic bodies are dependent on p62 for their formation and p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy.
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates
Serhiy Pankiv,Terje Høyvarde Clausen,Trond Lamark,Andreas Brech,Jack-Ansgar Bruun,Heidi Outzen,Aud Øvervatn,Geir Bjørkøy,Terje Johansen,Fromthe ‡ BiochemistryDepartment +9 more
TL;DR: In this article, the authors showed that the polyubiquitin-binding protein p62/SQSTM1 is degraded by autophagy by using a 22-residue sequence of p62 containing an evolutionarily conserved motif.
Journal ArticleDOI
A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates
Vladimir Kirkin,Trond Lamark,Yu-shin Sou,Geir Bjørkøy,Jennifer L. Nunn,Jack-Ansgar Bruun,Elena Shvets,David G. McEwan,Terje Høyvarde Clausen,Philipp Wild,Ivana Bilusic,Jean Philippe Theurillat,Aud Øvervatn,Tetsuro Ishii,Zvulun Elazar,Masaaki Komatsu,Ivan Dikic,Terje Johansen +17 more
TL;DR: NBR1 (neighbor of BRCA1 gene 1) is an autophagy receptor containing LC3- and ubiquitin (Ub)-binding domains and it is proposed that NBR1 and p62 act as receptors for selective autophagosomal degradation of ubiquitinated targets.
Journal ArticleDOI
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.
Terje Høyvarde Clausen,Trond Lamark,Pauline Isakson,Kim D. Finley,Kenneth Bowitz Larsen,Andreas Brech,Aud Øvervatn,Harald Stenmark,Geir Bjørkøy,Anne Simonsen,Terje Johansen +10 more
TL;DR: It is shown here that p62 is required to recruit the large phosphoinositide-binding protein ALFY to cytoplasmic p62 bodies generated upon amino acid starvation or puromycin-treatment, demonstrating that ALFY is required for autophagic degradation of p62-associated ubiquitinated proteins in vivo.