J
Jean Philippe Theurillat
Researcher at Broad Institute
Publications - 8
Citations - 5239
Jean Philippe Theurillat is an academic researcher from Broad Institute. The author has contributed to research in topics: SPOP & Cancer. The author has an hindex of 7, co-authored 7 publications receiving 4574 citations. Previous affiliations of Jean Philippe Theurillat include University of Lugano & Massachusetts Institute of Technology.
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Journal ArticleDOI
A landscape of driver mutations in melanoma
Eran Hodis,Ian R. Watson,Ian R. Watson,Gregory V. Kryukov,Gregory V. Kryukov,Gregory V. Kryukov,Stefan T. Arold,Marcin Imielinski,Jean Philippe Theurillat,Elizabeth Nickerson,Daniel Auclair,Liren Li,Liren Li,Chelsea S. Place,Daniel DiCara,Alex H. Ramos,Alex H. Ramos,Michael S. Lawrence,Kristian Cibulskis,Andrey Sivachenko,Douglas Voet,Gordon Saksena,Nicolas Stransky,Robert C. Onofrio,Wendy Winckler,Kristin G. Ardlie,Nikhil Wagle,Nikhil Wagle,Jennifer A. Wargo,Kelly Chong,Donald L. Morton,Katherine Stemke-Hale,Guo Chen,Michael S. Noble,Matthew Meyerson,John E. Ladbury,Michael A. Davies,Jeffrey E. Gershenwald,Stephan N. Wagner,Dave S.B. Hoon,Dirk Schadendorf,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Gad Getz,Levi A. Garraway,Lynda Chin +46 more
TL;DR: The spectrum of driver mutations provided unequivocal genomic evidence for a direct mutagenic role of UV light in melanoma pathogenesis, providing oncogenic insights in BRAF- and NRAS-driven melanoma as well as those without known NRAS/BRAF mutations.
Journal ArticleDOI
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Christopher E. Barbieri,Sylvan C. Baca,Sylvan C. Baca,Michael S. Lawrence,Francesca Demichelis,Francesca Demichelis,Mirjam Blattner,Jean Philippe Theurillat,Thomas A. White,Petar Stojanov,Eliezer M. Van Allen,Eliezer M. Van Allen,Nicolas Stransky,Elizabeth Nickerson,Sung Suk Chae,Gunther Boysen,Daniel Auclair,Robert C. Onofrio,Kyung Park,Naoki Kitabayashi,Theresa Y. MacDonald,Karen Sheikh,Terry Vuong,Candace Guiducci,Kristian Cibulskis,Andrey Sivachenko,Scott L. Carter,Gordon Saksena,Douglas Voet,Wasay M. Hussain,Alex H. Ramos,Alex H. Ramos,Wendy Winckler,Michelle C Redman,Kristin Ardlie,Ashutosh K. Tewari,Juan Miguel Mosquera,Niels J. Rupp,Peter J. Wild,Holger Moch,Colm Morrissey,Peter S. Nelson,Peter S. Nelson,Philip W. Kantoff,Stacey Gabriel,Todd R. Golub,Matthew Meyerson,Eric S. Lander,Eric S. Lander,Gad Getz,Mark A. Rubin,Levi A. Garraway +51 more
TL;DR: SPOP mutations may define a new molecular subtype of prostate cancer, with mutations involving the SPOP substrate-binding cleft in 6–15% of tumors across multiple independent cohorts.
Journal ArticleDOI
A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates
Vladimir Kirkin,Trond Lamark,Yu-shin Sou,Geir Bjørkøy,Jennifer L. Nunn,Jack-Ansgar Bruun,Elena Shvets,David G. McEwan,Terje Høyvarde Clausen,Philipp Wild,Ivana Bilusic,Jean Philippe Theurillat,Aud Øvervatn,Tetsuro Ishii,Zvulun Elazar,Masaaki Komatsu,Ivan Dikic,Terje Johansen +17 more
TL;DR: NBR1 (neighbor of BRCA1 gene 1) is an autophagy receptor containing LC3- and ubiquitin (Ub)-binding domains and it is proposed that NBR1 and p62 act as receptors for selective autophagosomal degradation of ubiquitinated targets.
Journal ArticleDOI
Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
Jean Philippe Theurillat,Jean Philippe Theurillat,Namrata D. Udeshi,Wesley J. Errington,Wesley J. Errington,Tanya Svinkina,Sylvan C. Baca,Marius S. Pop,Marius S. Pop,Peter J. Wild,Mirjam Blattner,Anna C. Groner,Mark A. Rubin,Mark A. Rubin,Holger Moch,Gilbert G. Privé,Gilbert G. Privé,Steven A. Carr,Levi A. Garraway +18 more
TL;DR: Analysis of changes in the ubiquitin landscape induced by prostate cancer–associated mutations of SPOP, an E3 ubiquit in ligase substrate-binding protein, provides a framework to decipher tumorigenic mechanisms linked to dysregulated ubiquitylation.
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Christopher E. Barbieri,Sylvan C. Baca,Sylvan C. Baca,Michael S. Lawrence,Francesca Demichelis,Francesca Demichelis,Mirjam Blattner,Jean Philippe Theurillat,Thomas A. White,Petar Stojanov,Eliezer M. Van Allen,Eliezer M. Van Allen,Nicolas Stransky,Elizabeth Nickerson,Sung Suk Chae,Gunther Boysen,Daniel Auclair,Robert C. Onofrio,Kyung Park,Naoki Kitabayashi,Theresa Y. MacDonald,Karen Sheikh,Terry Vuong,Candace Guiducci,Kristian Cibulskis,Andrey Sivachenko,Scott L. Carter,Gordon Saksena,Douglas Voet,Wasay M. Hussain,Alex H. Ramos,Alex H. Ramos,Wendy Winckler,Michelle C Redman,Kristin Ardlie,Ashutosh K. Tewari,Juan Miguel Mosquera,Niels J. Rupp,Peter J. Wild,Holger Moch,Colm Morrissey,Peter S. Nelson,Peter S. Nelson,Philip W. Kantoff,Stacey Gabriel,Todd R. Golub,Matthew Meyerson,Eric S. Lander,Eric S. Lander,Gad Getz,Mark A. Rubin,Levi A. Garraway +51 more
TL;DR: The National Human Genome Research Institute (U.S.) (Large Scale Sequencing Program Grant U54 HG003067) as discussed by the authors has provided a grant for large scale sequencing.